Codium fragile F2 sensitize colorectal cancer cells to TRAIL-induced apoptosis via c-FLIP ubiquitination
- Authors
- Park, Seong Hye; Kim, Jung Lim; Jeong, Soyeon; Kim, Bo Ram; Na, Yoo Jin; Jo, Min Jee; Yun, Hye Kyeong; Jeong, Yoon A.; Kim, Dae Yeong; Kim, Bu Gyeom; You, SangGuan; Oh, Sang Cheul; Lee, Dae-Hee
- Issue Date
- 1-Jan-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Codium extracts (CE); TRAIL; c-FLIP; Ubiquitination
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.508, no.1, pp.1 - 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 508
- Number
- 1
- Start Page
- 1
- End Page
- 8
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/68365
- DOI
- 10.1016/j.bbrc.2018.10.159
- ISSN
- 0006-291X
- Abstract
- This study demonstrates that combined treatment with subtoxic doses of Codium extracts (CE), a flavonoid found in many fruits and vegetables, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), induces apoptosis in TRAIL-resistant colorectal cancer (CRC) cells. Effective induction of apoptosis by combined treatment with CE and TRAIL was not blocked by BcI-xL overexpression, which is known to confer resistance to various chemotherapeutic agents. While TRAIL-mediated proteolytic processing of procaspase-3 was partially blocked in various CRC cells treated with TRAIL alone, co-treatment with CE efficiently recovered TRAIL-induced caspase activation. We observed that CE treatment of CRC cells did not change the expression of anti-apoptotic proteins and pro-apoptotic proteins, including death receptors (DR4 and DRS). However, CE treatment markedly reduced the protein level of the short form of the cellular FLICE-inhibitory protein (c-FLIPS), an inhibitor of caspase-8, via proteasome-mediated degradation. Collectively, these observations show that CE recovers TRAIL sensitivity in various CRC cells via down-regulation of c-FLIPS. (C) 2018 Published by Elsevier Inc.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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