Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model
DC Field | Value | Language |
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dc.contributor.author | Yi, Kyong Wook | - |
dc.contributor.author | Mamillapalli, Ramanaiah | - |
dc.contributor.author | Sahin, Cagdas | - |
dc.contributor.author | Song, Jaeyen | - |
dc.contributor.author | Tal, Reshef | - |
dc.contributor.author | Taylor, Hugh S. | - |
dc.date.accessioned | 2021-09-01T21:53:21Z | - |
dc.date.available | 2021-09-01T21:53:21Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 0006-3363 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68436 | - |
dc.description.abstract | Successful implantation and pregnancy is dependent on sufficient endometrial growth during each reproductive cycle. Here, we report the therapeutic effect of either bone marrow-derived cells (BMDCs) or the stem cell chemo-attractant C-X-C motif chemokine 12 (CXCL12) on endometrial receptivity in a murine ethanol induced thin endometrium model. Endometrial epithelial area was significantly increased in mice treated with BMDCs, CXCL12, or by co-treatment with both compared with PBS-treated controls. Ki-67 and CD31 immunoreactivity was significantly higher in mice treated with either BMDCs, CXCL12, or both. The mRNA expression levels of endometrial receptivity markers leukemia inhibitory factor, interleukin-1 beta, and integrin beta-3 were increased in mice treated with either BMDCs, CXCL12, or both. The mRNA levels of matrix metalloproteinase-2 and -9 were significantly decreased by BMDCs but not by CXCL12. Pregnancy rates and litter size were increased after either treatment. Both BMDCs and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. Our findings indicate the potential therapeutic effects of BMDCs and CXCL12 on infertility related to thin endometrium. Bone marrow-derived cells and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. Bone marrow-derived cells and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.subject | HEMATOPOIETIC PROGENITOR CELLS | - |
dc.subject | COLONY-STIMULATING FACTOR | - |
dc.subject | IN-VITRO FERTILIZATION | - |
dc.subject | STEM-CELLS | - |
dc.subject | TISSUE REGENERATION | - |
dc.subject | PREGNANCY RATES | - |
dc.subject | THICKNESS | - |
dc.subject | IMPLANTATION | - |
dc.subject | SDF-1 | - |
dc.subject | ANGIOGENESIS | - |
dc.title | Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yi, Kyong Wook | - |
dc.identifier.doi | 10.1093/biolre/ioy175 | - |
dc.identifier.scopusid | 2-s2.0-85059527940 | - |
dc.identifier.wosid | 000481417000009 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF REPRODUCTION, v.100, no.1, pp.61 - 70 | - |
dc.relation.isPartOf | BIOLOGY OF REPRODUCTION | - |
dc.citation.title | BIOLOGY OF REPRODUCTION | - |
dc.citation.volume | 100 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 61 | - |
dc.citation.endPage | 70 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Reproductive Biology | - |
dc.relation.journalWebOfScienceCategory | Reproductive Biology | - |
dc.subject.keywordPlus | HEMATOPOIETIC PROGENITOR CELLS | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | IN-VITRO FERTILIZATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | TISSUE REGENERATION | - |
dc.subject.keywordPlus | PREGNANCY RATES | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | SDF-1 | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordAuthor | bone marrow-derived cells (BMDCs) | - |
dc.subject.keywordAuthor | CXCL12 | - |
dc.subject.keywordAuthor | thin endometrium | - |
dc.subject.keywordAuthor | infertility | - |
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