Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model
- Authors
- Yi, Kyong Wook; Mamillapalli, Ramanaiah; Sahin, Cagdas; Song, Jaeyen; Tal, Reshef; Taylor, Hugh S.
- Issue Date
- 1월-2019
- Publisher
- OXFORD UNIV PRESS INC
- Keywords
- bone marrow-derived cells (BMDCs); CXCL12; thin endometrium; infertility
- Citation
- BIOLOGY OF REPRODUCTION, v.100, no.1, pp.61 - 70
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOLOGY OF REPRODUCTION
- Volume
- 100
- Number
- 1
- Start Page
- 61
- End Page
- 70
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/68436
- DOI
- 10.1093/biolre/ioy175
- ISSN
- 0006-3363
- Abstract
- Successful implantation and pregnancy is dependent on sufficient endometrial growth during each reproductive cycle. Here, we report the therapeutic effect of either bone marrow-derived cells (BMDCs) or the stem cell chemo-attractant C-X-C motif chemokine 12 (CXCL12) on endometrial receptivity in a murine ethanol induced thin endometrium model. Endometrial epithelial area was significantly increased in mice treated with BMDCs, CXCL12, or by co-treatment with both compared with PBS-treated controls. Ki-67 and CD31 immunoreactivity was significantly higher in mice treated with either BMDCs, CXCL12, or both. The mRNA expression levels of endometrial receptivity markers leukemia inhibitory factor, interleukin-1 beta, and integrin beta-3 were increased in mice treated with either BMDCs, CXCL12, or both. The mRNA levels of matrix metalloproteinase-2 and -9 were significantly decreased by BMDCs but not by CXCL12. Pregnancy rates and litter size were increased after either treatment. Both BMDCs and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. Our findings indicate the potential therapeutic effects of BMDCs and CXCL12 on infertility related to thin endometrium. Bone marrow-derived cells and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium. Bone marrow-derived cells and CXCL12 displayed a comparable efficacy on endometrial regeneration in mice with thin endometrium.
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