Sequential simulation computed tomography allows assessment of internal rectal movements during preoperative chemoradiotherapy in rectal cancer

Abstract

Purposes: The purpose of this study was to assess the internal rectal movement and to determine the factors related to extensive internal rectal movement using sequential simulation computed tomography (CT) images. Materials and Methods: From 2010 to 2015, 96 patients receiving long-course preoperative chemoradiotherapy were included in our retrospective study. The initial simulation CT (Isim-CT) and follow-up simulation CT (Fsim-CT) for a boost were registered according to the isocenters and bony structure. The rectums on Isim-CT and Fsim-CT were compared on four different axial planes as follows: (1) lower pubis symphysis (AX(VERYLOW)), (2) upper pubis symphysis (AX(LOW)), (3) superior rectum (AX(HIGH)), and (4) middle of AX(LOW) and AX(HIGH) (AX(MID)). The involved rectum in the planning target volume was evaluated. The maximal radial distances (MRD), the necessary radius from the end of Isim-CT rectum to cover entire Fsim-CT rectum, and the common area rate (CAR) of the rectum (CAR, (Isim-CT boolean AND Fsim-CT)/(Isim-CT)) were measured. Linear regression tests for the MRDs and logistic regression tests for the CARs were conducted. Results: The mean +/- standard deviation (mm) of MRDs and CAR < 80% for AX(VERYLOW), AX(LOW), AX(MID), and AX(HIGH) were 2.3 +/- 2.5 and 8.9%, 3.0 +/- 3.7 and 17.4%, 4.0 +/- 5.2 and 27.1%, and 4.1 +/- 5.2 and 25%, respectively. For MRDs and CARs, a higher axial level (AX(VERYLOW)/AX(MID-HIGH), P = 0.018 and P = 0.034, respectively), larger bladder volume (P = 0.054 and P = 0.017, respectively), smaller bowel gas extent (small/marked, P = 0.014 and P = 0.001, respectively), and increased bowel gas change (decrease/increase, both P < 0.001) in rectum were associated with extensive internal rectal movement in multivariate analyses. Conclusions: As a result of following internal rectal movement through sequential simulation CT, the rectum above the pubis symphysis needs a larger margin, and bladder volume and bowel gas should be closely observed.