Quantitative MALDI-TOF mass spectrometric analysis of biocidal polyhexamethylene guanidine (PHMG) oligomers in consumer products
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Jung-eun | - |
dc.contributor.author | Park, Myungjun | - |
dc.contributor.author | Lee, Jung-min | - |
dc.contributor.author | Song, Insu | - |
dc.contributor.author | Ju, Yunha | - |
dc.contributor.author | Lee, Choong Sik | - |
dc.contributor.author | Kwon, Jung-Hwan | - |
dc.contributor.author | Moon, Bongjin | - |
dc.contributor.author | Oh, Han Bin | - |
dc.date.accessioned | 2021-09-01T22:34:52Z | - |
dc.date.available | 2021-09-01T22:34:52Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1387-3806 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/68833 | - |
dc.description.abstract | In Korea, biocides, which were used for sterilizing household humidifiers, caused a large number of casualties. The biocides used were either guanidine-containing oligomers, such as polyhexamethylene guanidine (PHMG), or thiazolinone-based small molecules such as methylisothiazolinone/methylchloroisothiazolinone (MIT/CMIT). For the guanidine-containing oligomers, a quantitative analysis method has not yet been developed, as the quantification of the oligomers is very challenging due to their polydispersed molecular weight distribution. In this paper, we describe a new MALDI-TOF mass spectrometry (MS)-based quantitative analysis method for the PHMG oligomers contained in wet wipe products. Quantification was made using internal standard C-13 labeled PHMG oligomers that were custom synthesized. To get rid of matrix molecules, for example, polyethylene glycols (PEGs), included in the wet wipes, solid phase extraction (SPE) with an MCX SPE cartridge was carried out. In addition, an ionic liquid matrix (ILM) of 1-methylimadazolium alpha-cyano-4-hydroxycinnamate (1-MeIm-CHCA) was used to improve the reproducibility of the MALDI-TOF MS measurements. This new quantitative analysis method was validated, and good linearity was obtained in the calibration plot. This approach is expected to be equally applicable to other guanidine-containing oligomers, such as polyhexamethylene biguanide (PHMB) and oligo-(2-(2-ethoxy)-ethoxyethyl)-guanidinium-chloride (PGH) as well as to other consumer products. (C) 2018 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | IONIC-LIQUID MATRICES | - |
dc.subject | LASER-DESORPTION IONIZATION | - |
dc.subject | HUMIDIFIER DISINFECTANT | - |
dc.subject | SYNTHETIC-POLYMERS | - |
dc.subject | STRUCTURAL-CHARACTERIZATION | - |
dc.subject | RISK | - |
dc.subject | MS | - |
dc.title | Quantitative MALDI-TOF mass spectrometric analysis of biocidal polyhexamethylene guanidine (PHMG) oligomers in consumer products | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Jung-Hwan | - |
dc.identifier.doi | 10.1016/j.ijms.2018.10.001 | - |
dc.identifier.scopusid | 2-s2.0-85056609749 | - |
dc.identifier.wosid | 000453773300038 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v.435, pp.298 - 304 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | - |
dc.citation.volume | 435 | - |
dc.citation.startPage | 298 | - |
dc.citation.endPage | 304 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalResearchArea | Spectroscopy | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.relation.journalWebOfScienceCategory | Spectroscopy | - |
dc.subject.keywordPlus | IONIC-LIQUID MATRICES | - |
dc.subject.keywordPlus | LASER-DESORPTION IONIZATION | - |
dc.subject.keywordPlus | HUMIDIFIER DISINFECTANT | - |
dc.subject.keywordPlus | SYNTHETIC-POLYMERS | - |
dc.subject.keywordPlus | STRUCTURAL-CHARACTERIZATION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | MS | - |
dc.subject.keywordAuthor | Polyhexamethylene guanidine (PHMG) | - |
dc.subject.keywordAuthor | MALDI-TOF MS | - |
dc.subject.keywordAuthor | Ionic liquid matrix (ILM) | - |
dc.subject.keywordAuthor | Internal standard | - |
dc.subject.keywordAuthor | Isotope-Labeling | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.