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Quantitative MALDI-TOF mass spectrometric analysis of biocidal polyhexamethylene guanidine (PHMG) oligomers in consumer products

Authors
Bae, Jung-eunPark, MyungjunLee, Jung-minSong, InsuJu, YunhaLee, Choong SikKwon, Jung-HwanMoon, BongjinOh, Han Bin
Issue Date
1월-2019
Publisher
ELSEVIER SCIENCE BV
Keywords
Polyhexamethylene guanidine (PHMG); MALDI-TOF MS; Ionic liquid matrix (ILM); Internal standard; Isotope-Labeling
Citation
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v.435, pp.298 - 304
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume
435
Start Page
298
End Page
304
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/68833
DOI
10.1016/j.ijms.2018.10.001
ISSN
1387-3806
Abstract
In Korea, biocides, which were used for sterilizing household humidifiers, caused a large number of casualties. The biocides used were either guanidine-containing oligomers, such as polyhexamethylene guanidine (PHMG), or thiazolinone-based small molecules such as methylisothiazolinone/methylchloroisothiazolinone (MIT/CMIT). For the guanidine-containing oligomers, a quantitative analysis method has not yet been developed, as the quantification of the oligomers is very challenging due to their polydispersed molecular weight distribution. In this paper, we describe a new MALDI-TOF mass spectrometry (MS)-based quantitative analysis method for the PHMG oligomers contained in wet wipe products. Quantification was made using internal standard C-13 labeled PHMG oligomers that were custom synthesized. To get rid of matrix molecules, for example, polyethylene glycols (PEGs), included in the wet wipes, solid phase extraction (SPE) with an MCX SPE cartridge was carried out. In addition, an ionic liquid matrix (ILM) of 1-methylimadazolium alpha-cyano-4-hydroxycinnamate (1-MeIm-CHCA) was used to improve the reproducibility of the MALDI-TOF MS measurements. This new quantitative analysis method was validated, and good linearity was obtained in the calibration plot. This approach is expected to be equally applicable to other guanidine-containing oligomers, such as polyhexamethylene biguanide (PHMB) and oligo-(2-(2-ethoxy)-ethoxyethyl)-guanidinium-chloride (PGH) as well as to other consumer products. (C) 2018 Elsevier B.V. All rights reserved.
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생명과학대학 (환경생태공학부)
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