Intensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL CholesterolIntensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL Cholesterol
- Other Titles
- Intensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL Cholesterol
- Authors
- 심두선; 정명호; 김효수; 권현철; 승기배; 나승운; 채성철; 김종진; 차광수; 박종선; 윤정한; 채제건; 주승재; 최동주; 허승호; 성인환; 조명찬; 김두일; 오석규; 안태훈; 황진용
- Issue Date
- 2019
- Publisher
- 한국지질동맥경화학회
- Keywords
- Cholesterol; Myocardial infarction; Statins
- Citation
- 지질·동맥경화학회지, v.8, no.2, pp.208 - 220
- Indexed
- KCI
OTHER
- Journal Title
- 지질·동맥경화학회지
- Volume
- 8
- Number
- 2
- Start Page
- 208
- End Page
- 220
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/69428
- DOI
- 10.12997/jla.2019.8.2.208
- ISSN
- 2287-2892
- Abstract
- Objective: Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL.
Methods: A total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months.
Results: After 1:2 propensity matching, differences were not observed between less intensive (n=302) and more intensive statin (n=604) groups in incidence of cardiac death (0.3% vs. 0.3%) and hemorrhagic stroke (0.3% vs. 0.5%, p=0.727) at 12 months. Compared with the less intensive statin group, the more intensive statin group showed lower target-vessel revascularization (4.6% vs. 1.8%, p=0.027) and MACCE (11.6% vs. 7.0%, p=0.021). Major bleeding was not different between less intensive and more intensive statin groups (1.0% vs. 2.6%, p=0.118).
Conclusion: More intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy.
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