Creating a New Pathway in Corynebacterium glutamicum for the Production of Taurine as a Food Additive
DC Field | Value | Language |
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dc.contributor.author | Joo, Young-Chul | - |
dc.contributor.author | Ko, Young Jin | - |
dc.contributor.author | You, Seung Kyou | - |
dc.contributor.author | Shin, Sang Kyu | - |
dc.contributor.author | Hyeon, Jeong Eun | - |
dc.contributor.author | Musaad, Almisned Shuaa | - |
dc.contributor.author | Han, Sung Ok | - |
dc.date.accessioned | 2021-09-02T01:36:07Z | - |
dc.date.available | 2021-09-02T01:36:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-12-26 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/70865 | - |
dc.description.abstract | Taurine is a biologically and physiologically valuable food additive. However, commercial taurine production mainly relies on environmentally harmful chemical synthesis. Herein, for the first time in bacteria, we attempted to produce taurine in metabolically engineered Corynebacterium glutamicum. The taurine-producing strain was developed by introducing cs, cdo1, and csad genes. Interestingly, while the control strain could not produce taurine, the engineered strains successfully produced taurine via the newly introduced metabolic pathway. Furthermore, we investigated the effect of a deletion strain of the transcriptional repressor McbR gene on taurine production. As a result, sulfur accumulation and L-cysteine biosynthesis were reinforced by the McbR deletion strain, which further increased the taurine production by 2.3-fold. Taurine production of the final engineered strain Tau11 was higher than in other previously reported strains. This study demonstrated a potential approach for eco-friendly biosynthesis as an alternative to the chemical synthesis of a food additive. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | SULFUR METABOLISM | - |
dc.subject | DELETION | - |
dc.subject | CYSTEINE | - |
dc.subject | MCBR | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | DESIGN | - |
dc.subject | ACIDS | - |
dc.title | Creating a New Pathway in Corynebacterium glutamicum for the Production of Taurine as a Food Additive | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Sung Ok | - |
dc.identifier.doi | 10.1021/acs.jafc.8b05093 | - |
dc.identifier.scopusid | 2-s2.0-85059542527 | - |
dc.identifier.wosid | 000454751500013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.66, no.51, pp.13454 - 13463 | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 66 | - |
dc.citation.number | 51 | - |
dc.citation.startPage | 13454 | - |
dc.citation.endPage | 13463 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | SULFUR METABOLISM | - |
dc.subject.keywordPlus | DELETION | - |
dc.subject.keywordPlus | CYSTEINE | - |
dc.subject.keywordPlus | MCBR | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | ACIDS | - |
dc.subject.keywordAuthor | taurine production | - |
dc.subject.keywordAuthor | new pathway | - |
dc.subject.keywordAuthor | metabolic engineering | - |
dc.subject.keywordAuthor | Corynebacterium glutamicum | - |
dc.subject.keywordAuthor | food additive | - |
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