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Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration

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dc.contributor.authorShim, Kyu-Sik-
dc.contributor.authorKim, Hak-Jun-
dc.contributor.authorKim, Sung Eum-
dc.contributor.authorPark, Kyeongsoon-
dc.date.accessioned2021-09-02T01:36:13Z-
dc.date.available2021-09-02T01:36:13Z-
dc.date.created2021-06-19-
dc.date.issued2018-12-25-
dc.identifier.issn1226-086X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/70866-
dc.description.abstractIn this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE INC-
dc.subjectSTEM-CELLS-
dc.subjectADIPOSE-TISSUE-
dc.subjectDRUG-DELIVERY-
dc.subjectDIFFERENTIATION-
dc.subjectBMP-2-
dc.subjectIMMOBILIZATION-
dc.subjectNANOPARTICLES-
dc.subjectSCAFFOLDS-
dc.subjectBIOCERAMICS-
dc.subjectFABRICATION-
dc.titleSimple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Hak-Jun-
dc.contributor.affiliatedAuthorKim, Sung Eum-
dc.identifier.doi10.1016/j.jiec.2018.07.048-
dc.identifier.scopusid2-s2.0-85051048125-
dc.identifier.wosid000452579600027-
dc.identifier.bibliographicCitationJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.68, pp.220 - 228-
dc.relation.isPartOfJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY-
dc.citation.titleJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY-
dc.citation.volume68-
dc.citation.startPage220-
dc.citation.endPage228-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART002414638-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryEngineering, Chemical-
dc.subject.keywordPlusSTEM-CELLS-
dc.subject.keywordPlusADIPOSE-TISSUE-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusBMP-2-
dc.subject.keywordPlusIMMOBILIZATION-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusSCAFFOLDS-
dc.subject.keywordPlusBIOCERAMICS-
dc.subject.keywordPlusFABRICATION-
dc.subject.keywordAuthorSurface biofunctionalization-
dc.subject.keywordAuthorBiphasic calcium phosphate-
dc.subject.keywordAuthorAlendronate-
dc.subject.keywordAuthorHeparin-
dc.subject.keywordAuthorOsteogenesis-
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