Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration
- Authors
- Shim, Kyu-Sik; Kim, Hak-Jun; Kim, Sung Eum; Park, Kyeongsoon
- Issue Date
- 25-12월-2018
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Surface biofunctionalization; Biphasic calcium phosphate; Alendronate; Heparin; Osteogenesis
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.68, pp.220 - 228
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 68
- Start Page
- 220
- End Page
- 228
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/70866
- DOI
- 10.1016/j.jiec.2018.07.048
- ISSN
- 1226-086X
- Abstract
- In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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