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Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

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dc.contributor.authorSingh, Hardev-
dc.contributor.authorKim, Seo Jin-
dc.contributor.authorKang, Dong Hoon-
dc.contributor.authorKim, Hye-Ri-
dc.contributor.authorSharma, Amit-
dc.contributor.authorKim, Won Young-
dc.contributor.authorKang, Chulhun-
dc.contributor.authorKim, Jong Seung-
dc.date.accessioned2021-09-02T03:33:47Z-
dc.date.available2021-09-02T03:33:47Z-
dc.date.created2021-06-19-
dc.date.issued2018-11-11-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/71858-
dc.description.abstractHerein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherROYAL SOC CHEMISTRY-
dc.subjectHEPATOCELLULAR-CARCINOMA-
dc.subjectIN-VIVO-
dc.subjectCANCER-THERAPY-
dc.subjectLIVER-CANCER-
dc.subjectCHEMOTHERAPY-
dc.subjectPRODRUG-
dc.subjectAGENTS-
dc.subjectTHERANOSTICS-
dc.subjectDOXORUBICIN-
dc.subjectACTIVATION-
dc.titleGlycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Jong Seung-
dc.identifier.doi10.1039/c8cc05175e-
dc.identifier.scopusid2-s2.0-85055622506-
dc.identifier.wosid000448823200015-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, v.54, no.87, pp.12353 - 12356-
dc.relation.isPartOfCHEMICAL COMMUNICATIONS-
dc.citation.titleCHEMICAL COMMUNICATIONS-
dc.citation.volume54-
dc.citation.number87-
dc.citation.startPage12353-
dc.citation.endPage12356-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusHEPATOCELLULAR-CARCINOMA-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusCANCER-THERAPY-
dc.subject.keywordPlusLIVER-CANCER-
dc.subject.keywordPlusCHEMOTHERAPY-
dc.subject.keywordPlusPRODRUG-
dc.subject.keywordPlusAGENTS-
dc.subject.keywordPlusTHERANOSTICS-
dc.subject.keywordPlusDOXORUBICIN-
dc.subject.keywordPlusACTIVATION-
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