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Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Authors
Singh, HardevKim, Seo JinKang, Dong HoonKim, Hye-RiSharma, AmitKim, Won YoungKang, ChulhunKim, Jong Seung
Issue Date
11-11월-2018
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.54, no.87, pp.12353 - 12356
Indexed
SCIE
SCOPUS
Journal Title
CHEMICAL COMMUNICATIONS
Volume
54
Number
87
Start Page
12353
End Page
12356
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/71858
DOI
10.1039/c8cc05175e
ISSN
1359-7345
Abstract
Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
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