Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior
- Authors
- Kim, Bokyeong; Yoon, Sehyoun; Nakajima, Ryuichi; Lee, Hyo Jin; Lim, Hee Jeong; Lee, Yeon-Kyung; Choi, June-Seek; Yoon, Bong-June; Augustine, George J.; Baik, Ja-Hyun
- Issue Date
- 6-11월-2018
- Publisher
- NATL ACAD SCIENCES
- Keywords
- dopamine receptor; impulsivity; central amygdala; neural circuit; optogenetics
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.115, no.45, pp.E10730 - E10739
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Volume
- 115
- Number
- 45
- Start Page
- E10730
- End Page
- E10739
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/71880
- DOI
- 10.1073/pnas.1811664115
- ISSN
- 0027-8424
- Abstract
- Impulsivity is closely associated with addictive disorders, and changes in the brain dopamine system have been proposed to affect impulse control in reward-related behaviors. However, the central neural pathways through which the dopamine system controls impulsive behavior are still unclear. We found that the absence of the D2 dopamine receptor (D2R) increased impulsive behavior in mice, whereas restoration of D2R expression specifically in the central amygdala (CeA)of D2R knockout mice (Drd2(-/-)) normalized their enhanced impulsivity. Inhibitory synaptic output from D2R-expressing neurons in the CeA underlies modulation of impulsive behavior because optogenetic activation of D2R-positive inhibitory neurons that project from the CeA to the bed nucleus of the stria terminalis (BNST) attenuate such behavior. Our identification of the key contribution of D2R-expressing neurons in the CeA. BNST circuit to the control of impulsive behavior reveals a pathway that could serve as a target for approaches to the management of neuropsychiatric disorders associated with impulsivity.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - School of Psychology > School of Psychology > 1. Journal Articles
- College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
- Graduate School > Department of Life Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.