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Balancing antimicrobial performance with hemocompatibility in amphiphilic homopolymers
- Authors
- Zhu, Zhiyuan; Jeong, Gookyeong; Kim, Seung-Jin; Gadwal, Ikhlas; Choe, Youngson; Bang, Joona; Oh, Min-Kyu; Khan, Anzar; Rao, Jingyi
- Issue Date
- 1-11월-2018
- Publisher
- WILEY
- Keywords
- amphiphilic polymers; antibacterial polymers; poly(glycidyl methacrylate); sequential post-polymerization modification; thiol-epoxy reaction
- Citation
- JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, v.56, no.21, pp.2391 - 2396
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- Volume
- 56
- Number
- 21
- Start Page
- 2391
- End Page
- 2396
- ISSN
- 0887-624X
- Abstract
- This work establishes amphiphilic polymethacrylates as new antimicrobial candidates that can be synthesized through a combination of controlled free radical polymerization and sequential postpolymerization modification protocols. When conjugated with a polyethylene glycol segment, the block copolymers exhibit a balanced performance between high antibacterial activity and high hemocompatibility.
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