Effects of Orally-Administered Bifidobacterium animalis subsp lactis Strain BB12 on Dextran Sodium Sulfate-Induced Colitis in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chae, Jung Min | - |
dc.contributor.author | Heo, Wan | - |
dc.contributor.author | Cho, Hyung Taek | - |
dc.contributor.author | Lee, Dong Hun | - |
dc.contributor.author | Kim, Jun Ho | - |
dc.contributor.author | Rhee, Min Suk | - |
dc.contributor.author | Park, Tae-Sik | - |
dc.contributor.author | Kim, Yong Ki | - |
dc.contributor.author | Lee, Jin Hyup | - |
dc.contributor.author | Kim, Young Jun | - |
dc.date.accessioned | 2021-09-02T04:10:33Z | - |
dc.date.available | 2021-09-02T04:10:33Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/71944 | - |
dc.description.abstract | Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Intestinal epithelial cells (IECs) constitute barrier surfaces and play a critical role in maintaining gut health. Dysregulated immune responses and destruction of IECs disrupt intestinal balance. Dextran sodium sulfate (DSS) is the most widely used chemical for inducing colitis in animals, and its treatment induces colonic inflammation, acute diarrhea, and shortening of the intestine, with clinical and histological similarity to human UC. Current treatments for this inflammatory disorder have poor tolerability and insufficient therapeutic efficacy, and thus, alternative therapeutic approaches are required. Recently, dietary supplements with probiotics have emerged as promising interventions by alleviating disturbances in the indigenous microflora in UC. Thus, we hypothesized that the probiotic Bifidobacterium animalis subsp. lactis strain BB12 could protect against the development of colitis in a DSS-induced mouse model of UC. In the present study, oral administration of BB12 markedly ameliorated DSS-induced colitis, accompanied by reduced tumor necrosis factor-alpha-mediated IEC apoptosis. These findings indicate that the probiotic strain BB12 can alleviate DSS-induced colitis and suggest a novel mechanism of communication between probiotic microorganisms and intestinal epithelia, which increases intestinal cell survival by modulating pro-apoptotic cytokine expression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.subject | APOPTOSIS | - |
dc.subject | CELLS | - |
dc.subject | NECROSIS | - |
dc.subject | DISEASES | - |
dc.title | Effects of Orally-Administered Bifidobacterium animalis subsp lactis Strain BB12 on Dextran Sodium Sulfate-Induced Colitis in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Heo, Wan | - |
dc.contributor.affiliatedAuthor | Rhee, Min Suk | - |
dc.contributor.affiliatedAuthor | Lee, Jin Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Young Jun | - |
dc.identifier.doi | 10.4014/jmb.1805.05072 | - |
dc.identifier.scopusid | 2-s2.0-85058902968 | - |
dc.identifier.wosid | 000451437200004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.28, no.11, pp.1800 - 1805 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1800 | - |
dc.citation.endPage | 1805 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002406024 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordAuthor | Probiotics | - |
dc.subject.keywordAuthor | colitis | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | apoptosis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.