S-Nitrosoglutathione loaded poly(lactic-co-glycolic acid) microparticles for prolonged nitric oxide release and enhanced healing of methicillin-resistant Staphylococcus aureus-infected wounds
- Authors
- Hlaing, Shwe Phyu; Kim, Jihyun; Lee, Juho; Hasan, Nurhasni; Cao, Jiafu; Naeem, Muhammad; Lee, Eun Hee; Shin, Jae Ho; Jung, Yunjin; Lee, Bok-Leul; Jhun, Byung Hak; Yoo, Jin-Wook
- Issue Date
- Nov-2018
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Nitric oxide; S-nitrosoglutathione; Poly (lactic-co-glycolic acid) microparticles; Methicillin-resistant Staphylococcus aureus; Wound healing
- Citation
- EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.132, pp.94 - 102
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Volume
- 132
- Start Page
- 94
- End Page
- 102
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/72009
- DOI
- 10.1016/j.ejpb.2018.09.009
- ISSN
- 0939-6411
- Abstract
- Methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds have become a significant clinical issue worldwide. Recently, nitric oxide (NO) has emerged as a potent antibacterial agent against MRSA infections and a wound-healing enhancer. Nevertheless, clinical applications of NO have been largely restricted by its gaseous state and short half-life. In this study, our aim was to develop S-nitrosoglutathione (GSNO, an endogenous NO donor)-loaded poly(lactic-co-glycolic acid) [PLGA] microparticles (GSNO-MPs) that release NO over a prolonged period, to accelerate the healing of MRSA-infected wounds with less frequent dosing. GSNO was successfully encapsulated into PLGA microparticles by a solid-in-oil-in-water emulsion solvent evaporation method. Scanning electron microscopy and X-ray diffraction analyses confirmed the successful fabrication of GSNO-MPs. The latter released NO in a prolonged manner over 7 days and exerted a remarkable antibacterial activity against MRSA in a concentration- and time-dependent manner. Moreover, GSNO-MPs had good antibacterial efficacy and were found to accelerate wound healing in a mouse model of MRSA-infected wounds. Therefore, NO-releasing MPs devised in this study may be a promising option for the treatment of cutaneous wounds infected by drug-resistant bacteria such as MRSA.
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