Synthesis and Evaluation of Manganese(II)-Based Ethylenediaminetetraacetic Acid Ethoxybenzyl Conjugate as a Highly Stable Hepatobiliary Magnetic Resonance Imaging Contrast Agent
- Authors
- Islam, Md. Kamrul; Kim, Soyeon; Kim, Hee-Kyung; Kim, Yeoun-Hee; Lee, Young-Mi; Choi, Garam; Baek, Ah Rum; Sung, Bo Kyung; Kim, Minsup; Cho, Art E.; Kang, Hyojeung; Lee, Gang-Ho; Choi, Seon Hee; Lee, Taekwan; Park, Ji-Ae; Chang, Yongmin
- Issue Date
- 11월-2018
- Publisher
- AMER CHEMICAL SOC
- Citation
- BIOCONJUGATE CHEMISTRY, v.29, no.11, pp.3614 - 3625
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCONJUGATE CHEMISTRY
- Volume
- 29
- Number
- 11
- Start Page
- 3614
- End Page
- 3625
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/72012
- DOI
- 10.1021/acs.bioconjchem.8b00560
- ISSN
- 1043-1802
- Abstract
- In this study, we designed and synthesized a highly stable manganese (Mn2+)-based hepatobiliary complex by tethering an ethoxybenzyl (EOB) moiety with an ethylenediaminetetraacetic acid (EDTA) coordination cage as an alternative to the well-established hepatobiliary gadolinium (Gd3+) chelates and evaluated its usage as a T-1 hepatobiliary magnetic resonance imaging (MRI) contrast agent (CA). This new complex exhibits higher r(1) relaxivity (2.3 mM(-1) s(-1)) than clinically approved Mn2+-based hepatobiliary complex Mn-DPDP (1.6 mM(-1) s(-1)) at 1.5 T. Mn-EDTA-EOB shows much higher kinetic inertness than that of clinically approved Gd3+-based hepatobiliary MRI CAs, such as Gd-DTPA-EOB and Gd-BOPTA. In addition, in vivo biodistribution and MRI enhancement patterns of this new Mn2+ chelate are comparable to those of Gd3+-based hepatobiliary MRI CAs. The diagnostic efficacy of the new complex was demonstrated by its enhanced tumor detection sensitivity in a liver cancer model using in vivo MM.
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Collections - Graduate School > Department of Biotechnology and Bioinformatics > 1. Journal Articles
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