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Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica
- Authors
- Jin, Qinghao; Lee, Jin Woo; Jang, Hari; Lee, Hye Lim; Kim, Jun Gu; Wu, Wanying; Lee, Dongho; Kim, Eun-Hee; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwan, Bang Yeon
- Issue Date
- 11월-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Inula japonica; Asteraceae; Sesquiterpene trimer; Sesquiterpenes dimer; Cytotoxic activity; Nitric oxide
- Citation
- PHYTOCHEMISTRY, v.155, pp.107 - 113
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOCHEMISTRY
- Volume
- 155
- Start Page
- 107
- End Page
- 113
- ISSN
- 0031-9422
- Abstract
- An undescribed unusual sesquiterpene trimer and three sesquiterpene dimers were isolated from the flowers of Inula japonica. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data as well as HRESIMS data. Inulajaponicolide A has an undescribed carbon skeleton comprising of one xanthanolide and two guaianolide units with the linkage mode of C-11/C-3' and C-11'C-1" via a Diels-Alder cycloaddition reaction. Inulajaponicolides C and D exhibited moderate cytotoxic activity against A 549 and NCI-H460 human cancer cell lines with IC50 values ranging from 8.5 to 17.8 mu M. Inulajaponicolides A-D and lineariifolianoid A possessed significant inhibitory potency against nitric oxide production in LPS-induced RAW264.7 cells with IC50 values ranging from 1.0 to 4.1 M.
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