Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica

Authors
Jin, QinghaoLee, Jin WooJang, HariLee, Hye LimKim, Jun GuWu, WanyingLee, DonghoKim, Eun-HeeKim, YoungsooHong, Jin TaeLee, Mi KyeongHwan, Bang Yeon
Issue Date
11월-2018
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Inula japonica; Asteraceae; Sesquiterpene trimer; Sesquiterpenes dimer; Cytotoxic activity; Nitric oxide
Citation
PHYTOCHEMISTRY, v.155, pp.107 - 113
Indexed
SCIE
SCOPUS
Journal Title
PHYTOCHEMISTRY
Volume
155
Start Page
107
End Page
113
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/72072
DOI
10.1016/j.phytochem.2018.07.008
ISSN
0031-9422
Abstract
An undescribed unusual sesquiterpene trimer and three sesquiterpene dimers were isolated from the flowers of Inula japonica. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data as well as HRESIMS data. Inulajaponicolide A has an undescribed carbon skeleton comprising of one xanthanolide and two guaianolide units with the linkage mode of C-11/C-3' and C-11'C-1" via a Diels-Alder cycloaddition reaction. Inulajaponicolides C and D exhibited moderate cytotoxic activity against A 549 and NCI-H460 human cancer cell lines with IC50 values ranging from 8.5 to 17.8 mu M. Inulajaponicolides A-D and lineariifolianoid A possessed significant inhibitory potency against nitric oxide production in LPS-induced RAW264.7 cells with IC50 values ranging from 1.0 to 4.1 M.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Plant Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Dong ho photo

Lee, Dong ho
식물생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE