Association between Genetic Variant of Apolipoprotein C3 and Incident Hypertension Stratified by Obesity and Physical Activity in Korea
DC Field | Value | Language |
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dc.contributor.author | Jo, Garam | - |
dc.contributor.author | Kwak, So-Young | - |
dc.contributor.author | Kim, Ji Young | - |
dc.contributor.author | Lim, Hyunjung | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.date.accessioned | 2021-09-02T04:28:32Z | - |
dc.date.available | 2021-09-02T04:28:32Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72090 | - |
dc.description.abstract | Apolipoprotein C3 (APOC3) is an important regulator of lipoprotein metabolism, and has been shown to be strongly associated with hypertriglyceridemia. We tested whether triglyceride-influencing genetic variants at APOC3 (T-455C, C-482T, C1100T, and SstI) are associated with the onset of hypertension (HTN) among Korean adults stratified by lifestyle-related factors in the Ansung-Ansan cohort within the Korean Genome and Epidemiology Study. After excluding participants with preexisting cancer, cardiovascular diseases, diabetes, and HTN, a total of 5239 men and women were included at baseline (2001-2002), and followed up for a median of 9.8 years. Carriers of the C allele of C1100T with body mass index <25 kg/m(2) showed a significantly lower HTN risk (hazard ratio (HR) than non-carriers: 0.87, 95% confidence interval (CI): 0.77-0.98) after adjusting for covariates. In addition, carriers of the C allele of T-455C and the T allele of C-482T with low physical activity had lower incident HTN than non-carriers (HR: 1.14, 95% CI: 1.03-1.26; HR: 1.13, 95% CI: 1.02-1.25). Our results suggest that genotype effects in APOC3 on HTN risk have been shown in lean carriers of the C allele of C1100T and in less active people having the C allele of T-455C and T allele of C-482T in a large sample of the Korean population. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | OF-FUNCTION MUTATIONS | - |
dc.subject | III GENE | - |
dc.subject | ENDOTHELIAL DYSFUNCTION | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | CELL-ADHESION | - |
dc.subject | RISK | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | APOC3 | - |
dc.subject | TRIGLYCERIDES | - |
dc.subject | DISEASE | - |
dc.title | Association between Genetic Variant of Apolipoprotein C3 and Incident Hypertension Stratified by Obesity and Physical Activity in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.3390/nu10111595 | - |
dc.identifier.scopusid | 2-s2.0-85055768038 | - |
dc.identifier.wosid | 000451547700033 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.10, no.11 | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | OF-FUNCTION MUTATIONS | - |
dc.subject.keywordPlus | III GENE | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | APOC3 | - |
dc.subject.keywordPlus | TRIGLYCERIDES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | apolipoprotein C3 | - |
dc.subject.keywordAuthor | genetic variant | - |
dc.subject.keywordAuthor | hypertension | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | physical activity | - |
dc.subject.keywordAuthor | triglyceride | - |
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