Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Association between Genetic Variant of Apolipoprotein C3 and Incident Hypertension Stratified by Obesity and Physical Activity in Korea

Authors
Jo, GaramKwak, So-YoungKim, Ji YoungLim, HyunjungShin, Min-Jeong
Issue Date
11월-2018
Publisher
MDPI
Keywords
apolipoprotein C3; genetic variant; hypertension; obesity; physical activity; triglyceride
Citation
NUTRIENTS, v.10, no.11
Indexed
SCIE
SCOPUS
Journal Title
NUTRIENTS
Volume
10
Number
11
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/72090
DOI
10.3390/nu10111595
ISSN
2072-6643
Abstract
Apolipoprotein C3 (APOC3) is an important regulator of lipoprotein metabolism, and has been shown to be strongly associated with hypertriglyceridemia. We tested whether triglyceride-influencing genetic variants at APOC3 (T-455C, C-482T, C1100T, and SstI) are associated with the onset of hypertension (HTN) among Korean adults stratified by lifestyle-related factors in the Ansung-Ansan cohort within the Korean Genome and Epidemiology Study. After excluding participants with preexisting cancer, cardiovascular diseases, diabetes, and HTN, a total of 5239 men and women were included at baseline (2001-2002), and followed up for a median of 9.8 years. Carriers of the C allele of C1100T with body mass index <25 kg/m(2) showed a significantly lower HTN risk (hazard ratio (HR) than non-carriers: 0.87, 95% confidence interval (CI): 0.77-0.98) after adjusting for covariates. In addition, carriers of the C allele of T-455C and the T allele of C-482T with low physical activity had lower incident HTN than non-carriers (HR: 1.14, 95% CI: 1.03-1.26; HR: 1.13, 95% CI: 1.02-1.25). Our results suggest that genotype effects in APOC3 on HTN risk have been shown in lean carriers of the C allele of C1100T and in less active people having the C allele of T-455C and T allele of C-482T in a large sample of the Korean population.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE