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Flexible deep brain neural probe for localized stimulation and detection with metal guide

Authors
Kim, Jeong HunLee, Geon HuiKim, SeohyeonChung, Hyo WonLee, Joong HoonLee, Seung MinKang, Chong YunLee, Sang-Hoon
Issue Date
15-10월-2018
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Keywords
Deep brain stimulation; Implantable device; Flexible neural probe; Localized stimulation
Citation
BIOSENSORS & BIOELECTRONICS, v.117, pp.436 - 443
Indexed
SCIE
SCOPUS
Journal Title
BIOSENSORS & BIOELECTRONICS
Volume
117
Start Page
436
End Page
443
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/72486
DOI
10.1016/j.bios.2018.06.035
ISSN
0956-5663
Abstract
In this paper, we present the design, fabrication, and performance evaluation of a polyimide-based flexible neural probe for the precise site stimulation and recording in the deep brain. The probe consists of five electrodes: one for stimulation, another for ground and the other three for recording electrodes. This probe is designed to be foldable, enabling easy insertion into the deep brain via temporary tungsten guide sticks. Because of its small cross-sectional area and the flexibility of the polyimide, the probe causes minimum damage to the neural tissue and does not show any evidence of serious immune reactions such as high density of macrophage or microglia. Around the simulation electrodes, an additional ground electrode prevents the stimulation of the undesired sites in the brain. To ensure we stimulate the target point specifically, for instance STh in this study, we confirm through both finite element analyses and in vitro tests. With the additional ground electrodes, we observe the leakage power decreased by about 80%. To check the performance of the probe, we demonstrate animal experiments using rats, and neural spike signals from STh in the 7-mm deep brain are successfully recorded after implantation.
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Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles

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