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Treadmill Exercise Improves Motor Function by Suppressing Purkinje Cell Loss in Parkinson Disease Rats

Authors
Lee, Jae-MinKim, Tae-WoonPark, Sang-SeoHan, Jin-HeeShin, Mal-SoonLim, Baek-VinKim, Sang-HoonBaek, Seung-SooCho, Young SamKim, Khae Hawn
Issue Date
10월-2018
Publisher
KOREAN CONTINENCE SOC
Keywords
Parkinson disease; Rotenone, Cerebellum; Motor coordination; Treadmill exercise; Apoptosis
Citation
INTERNATIONAL NEUROUROLOGY JOURNAL, v.22, pp.S147 - S155
Indexed
SCIE
SCOPUS
KCI
Journal Title
INTERNATIONAL NEUROUROLOGY JOURNAL
Volume
22
Start Page
S147
End Page
S155
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/72554
DOI
10.5213/inj.1836226.113
ISSN
2093-4777
Abstract
Purpose: Rotenone is the most widely used neurotoxin for the making Parkinson disease (PD) animal model. The neurodegenerative disorder PD shows symptoms, such as slowness of movements, tremor at resting, rigidity, disturbance of gait, and instability of posture. We investigated whether treadmill running improves motor ability using rotenone-caused PD rats. The effect of treadmill running on PD was also assessed in relation with apoptosis of cerebellar Purkinje cells. Methods: Treadmill running was applied to the rats in the exercise groups for 30 minutes once a day for 4 weeks, starting 4 weeks after birth. We used rota-rod test for the determination of motor coordination and balance. In this experiment, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, immunohistochemistry for calbindin, glial fibrillary acidic protein (GFAP), Iba-1, and western blot analysis for Bax and Bcl-2 were performed. Results: Treadmill running enhanced motor balance and coordination by preventing the loss of Purkinje cells in the cerebellar vermis. Treadmill running suppressed PD-induced expression of GFAP-positive reactive astrocytes and Iba-1-positive microglia, showing that treadmill running suppressed reactive astrogliosis and microglia activation. Treadmill running suppressed TUNEL-positive cell number and Bax expression and enhanced Bcl-2 expression, demonstrating that treadmill running inhibited the progress of apoptosis in the cerebellum of rotenone-induced PD rats. Conclusions: Treadmill running improved motor ability of the rotenone-induced PD rats by inhibiting apoptosis in the cerebellum. Apoptosis suppressing effect of treadmill running on rotenone-induced PD was achieved via suppression of reactive astrocyte and inhibition of microglial activation.
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