External beam radiation therapy to hepatocellular carcinoma involving inferior vena cava and/or right atrium: A meta-analysis and systemic review
DC Field | Value | Language |
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dc.contributor.author | Rim, Chai Hong | - |
dc.contributor.author | Kim, Chul Yong | - |
dc.contributor.author | Yang, Dae Sik | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.date.accessioned | 2021-09-02T05:22:21Z | - |
dc.date.available | 2021-09-02T05:22:21Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/72560 | - |
dc.description.abstract | Purpose: Hepatocellular carcinoma (HCC) involving inferior vena cava (IVC) and/or right atrium (RA) is a very rare but serious disease. The objective of this meta-analysis was to assess efficacy and safety of external beam radiotherapy (EBRT) for HCC involving IVC and/or RA. Materials and methods: Systematic search of Pubmed, MEDLINE, EMBASE, and Cochrane library published was performed. Primary endpoints were 1-year overall survival (OS) rate and 2-year OS rates. Secondary endpoints were response rate, local control (LC) rate, and grade 3 toxicities. According to heterogeneity evaluated with Cochran Q test and I2 statistics, meta-analysis was performed using either random or fixed model. Results: A total of 8 studies and 9 cohorts were included, encompassing 164 patients. Pooled 1-and 2year OS rates were 53.6% (95% CI: 45.7-61.3%) and 36.9% (95% CI: 27.2-42.4%), respectively. Pooled response rate and LC rate were 59.2% (95% CI: 39.0-76.7%) and 83.8% (95% CI: 78.8-97.1%), respectively. Only one study reported 2 grade 3 toxicities, an esophageal rupture and a pulmonary embolism cases. The overall rate of possible grade 3 complications was 1.2% (2 of 164). Conclusions: EBRT is a feasible and safe option to palliate HCC with IVC and/or RA invasion. (C) 2018 Published by Elsevier B. V. Radiotherapy and Oncology | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | 3-DIMENSIONAL CONFORMAL RADIOTHERAPY | - |
dc.subject | TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION | - |
dc.subject | PORTAL-VEIN THROMBOSIS | - |
dc.subject | NATURAL-HISTORY | - |
dc.subject | TRANSARTERIAL CHEMOEMBOLIZATION | - |
dc.subject | TUMOR THROMBI | - |
dc.subject | GUIDELINES | - |
dc.subject | EMBOLISM | - |
dc.subject | PATIENT | - |
dc.subject | BIAS | - |
dc.title | External beam radiation therapy to hepatocellular carcinoma involving inferior vena cava and/or right atrium: A meta-analysis and systemic review | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rim, Chai Hong | - |
dc.contributor.affiliatedAuthor | Kim, Chul Yong | - |
dc.contributor.affiliatedAuthor | Yang, Dae Sik | - |
dc.contributor.affiliatedAuthor | Yoon, Won Sup | - |
dc.identifier.doi | 10.1016/j.radonc.2018.02.030 | - |
dc.identifier.scopusid | 2-s2.0-85044527562 | - |
dc.identifier.wosid | 000449458600018 | - |
dc.identifier.bibliographicCitation | RADIOTHERAPY AND ONCOLOGY, v.129, no.1, pp.123 - 129 | - |
dc.relation.isPartOf | RADIOTHERAPY AND ONCOLOGY | - |
dc.citation.title | RADIOTHERAPY AND ONCOLOGY | - |
dc.citation.volume | 129 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 123 | - |
dc.citation.endPage | 129 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | 3-DIMENSIONAL CONFORMAL RADIOTHERAPY | - |
dc.subject.keywordPlus | TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | PORTAL-VEIN THROMBOSIS | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | TRANSARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | TUMOR THROMBI | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | EMBOLISM | - |
dc.subject.keywordPlus | PATIENT | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Inferior vena cava | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.subject.keywordAuthor | Right atrium | - |
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