External beam radiation therapy to hepatocellular carcinoma involving inferior vena cava and/or right atrium: A meta-analysis and systemic review
- Authors
- Rim, Chai Hong; Kim, Chul Yong; Yang, Dae Sik; Yoon, Won Sup
- Issue Date
- 10월-2018
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Hepatocellular carcinoma; Inferior vena cava; Meta-analysis; Radiotherapy; Right atrium
- Citation
- RADIOTHERAPY AND ONCOLOGY, v.129, no.1, pp.123 - 129
- Indexed
- SCIE
SCOPUS
- Journal Title
- RADIOTHERAPY AND ONCOLOGY
- Volume
- 129
- Number
- 1
- Start Page
- 123
- End Page
- 129
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/72560
- DOI
- 10.1016/j.radonc.2018.02.030
- ISSN
- 0167-8140
- Abstract
- Purpose: Hepatocellular carcinoma (HCC) involving inferior vena cava (IVC) and/or right atrium (RA) is a very rare but serious disease. The objective of this meta-analysis was to assess efficacy and safety of external beam radiotherapy (EBRT) for HCC involving IVC and/or RA. Materials and methods: Systematic search of Pubmed, MEDLINE, EMBASE, and Cochrane library published was performed. Primary endpoints were 1-year overall survival (OS) rate and 2-year OS rates. Secondary endpoints were response rate, local control (LC) rate, and grade 3 toxicities. According to heterogeneity evaluated with Cochran Q test and I2 statistics, meta-analysis was performed using either random or fixed model. Results: A total of 8 studies and 9 cohorts were included, encompassing 164 patients. Pooled 1-and 2year OS rates were 53.6% (95% CI: 45.7-61.3%) and 36.9% (95% CI: 27.2-42.4%), respectively. Pooled response rate and LC rate were 59.2% (95% CI: 39.0-76.7%) and 83.8% (95% CI: 78.8-97.1%), respectively. Only one study reported 2 grade 3 toxicities, an esophageal rupture and a pulmonary embolism cases. The overall rate of possible grade 3 complications was 1.2% (2 of 164). Conclusions: EBRT is a feasible and safe option to palliate HCC with IVC and/or RA invasion. (C) 2018 Published by Elsevier B. V. Radiotherapy and Oncology
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