Comparison of radiation therapy modalities for hepatocellular carcinoma with portal vein thrombosis: A meta-analysis and systematic review
- Authors
- Rim, Chai Hong; Kim, Chul Yong; Yang, Dae Sik; Yoon, Won Sup
- Issue Date
- 10월-2018
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Radiotherapy; Hepatocellular carcinoma; Portal vein thrombosis; Selective internal radiotherapy; Stereotactic body radiotherapy
- Citation
- RADIOTHERAPY AND ONCOLOGY, v.129, no.1, pp.112 - 122
- Indexed
- SCIE
SCOPUS
- Journal Title
- RADIOTHERAPY AND ONCOLOGY
- Volume
- 129
- Number
- 1
- Start Page
- 112
- End Page
- 122
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/72571
- DOI
- 10.1016/j.radonc.2017.11.013
- ISSN
- 0167-8140
- Abstract
- Purpose: We performed a meta-analysis and systematic review to compare the radiotherapy (RT) modalities for hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT). Materials and methods: We searched the PubMed, EMBASE, Medline, and Cochrane library databases. The primary endpoint was the 1-year overall survival (OS), and response rate (RR), local control (LC), 2-year OS, and grade >= 3 toxicity incidence were evaluated as secondary endpoints. Results: Thirty-seven studies comprising 2513 patients were included. The pooled 1-year OS rates for the 3-dimensional conformal RT (3DCRT), selective internal RT (SIRT), and stereotactic body RT (SBRT) groups were 43.8% [ 95% confidence interval (CI): 37.6-50.2], 46.5% (95% CI: 37.7-55.6), and 48.5% (95% CI: 39.457.8). These inter-group differences were not statistically significant (p = 0.635). The pooled response rates were 51.3% (95% CI: 45.7-57.0), 33.3% (95% CI: 18.0-53.2), and 70.7 (95% CI: 63.7-76.8) for 3DCRT, SIRT, and SBRT groups, respectively; p = 0.001 and 0.031 for 3DCRT vs. SBRT and SIRT, respectively. The most common grade >= 3 complications were lymphocytopenia and bilirubin abnormalities in the 3DCRT and SIRT groups, respectively. Grade >= 3 complication was rare in SBRT group. Conclusions: OS did not differ among the modalities, although the response rates vary among modalities. (C) 2017 Elsevier B. V. All rights reserved. Radiotherapy and Oncology
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