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Fluorescent Molecular Rotors for Viscosity Sensors

Authors
Lee, Seung-ChulHeo, JeongyunWoo, Hee ChulLee, Ji-AhSeo, Young HunLee, Chang-LyoulKim, SehoonKwon, O-Pil
Issue Date
18-Sep-2018
Publisher
WILEY-V C H VERLAG GMBH
Keywords
fluorescence dynamics; fluorescent molecular rotors; microviscosity; molecular rotors; viscosity sensors
Citation
CHEMISTRY-A EUROPEAN JOURNAL, v.24, no.52, pp.13706 - 13718
Indexed
SCIE
SCOPUS
Journal Title
CHEMISTRY-A EUROPEAN JOURNAL
Volume
24
Number
52
Start Page
13706
End Page
13718
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/73083
DOI
10.1002/chem.201801389
ISSN
0947-6539
Abstract
Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent pi-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push-pull type pi-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed.
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