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Polygonatum sibiricum rhizome promotes sleep by regulating non-rapid eye movement and GABAergic/serotonergic receptors in rodent models

Authors
Jo, KyungaeSuh, Hyung JooChoi, Hyeon-Son
Issue Date
9월-2018
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Keywords
Polygonatum sibiricum; Insomnia; Sleep; Caffeine; gamma-aminobutyric acid; Vertebrate
Citation
BIOMEDICINE & PHARMACOTHERAPY, v.105, pp.167 - 175
Indexed
SCIE
SCOPUS
Journal Title
BIOMEDICINE & PHARMACOTHERAPY
Volume
105
Start Page
167
End Page
175
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/73196
DOI
10.1016/j.biopha.2018.05.115
ISSN
0753-3322
Abstract
The aim of this study is to investigate the sleep-promoting effect of a water extract of the Polygonatum sibiricum rhizome (PSE) in rodent models. PSE contained oleamide (0.10 mg/g extract) and glyceryl monolinoleate (0.17 mg/g extract), which are recognized as sleep-promoting substances. In pentobarbital-induced sleep model at hypnotic level, PSE (160 mg/kg) administration significantly decreased sleep latency time by 29% (2.7 min) and increased sleep duration time by 70% (68.4 min) compared with the normal control (3.8 min and 40.7 min, respectively). In the electroencephalography (EEG) analysis of rats, PSE-mediated sleep promotion accompanied the change of sleep architecture including increase of non-rapid eye movement (NREM) and decrease of REM. This sleep promoting effect was more obvious in caffeine-induced awakening model; total sleep time was increased by 40% along with increased NREM by PSE treatment M 160 mg/kg. In addition, PSE significantly increased the protein and mRNA levels of GABA(A)-R2 and 5-HT1A receptor, the major sleep-related neurotransmitter receptors. Furthermore, glyceryl monolinoleate and oleamide effectively bound to GABA(A) receptor in a competitive binding assay. These results indicate that PSE-mediated sleep-promoting effect is associated with the extension of NREM and upregulation of GABA(A)-R2 and 5-HT1A, and is mediated by binding to the GABA(A) receptor in vertebrate models.
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보건과학대학 (바이오시스템의과학부)
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