Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Multi-ethnic genome-wide association study for atrial fibrillation
- Authors
- Roselli, Carolina; Chaffin, Mark D.; Weng, Lu-Chen; Aeschbacher, Stefanie; Ahlberg, Gustav; Albert, Christine M.; Almgren, Peter; Alonso, Alvaro; Anderson, Christopher D.; Aragam, Krishna G.; Arking, Dan E.; Barnard, John; Bartz, Traci M.; Benjamin, Emelia J.; Bihlmeyer, Nathan A.; Bis, Joshua C.; Bloom, Heather L.; Boerwinkle, Eric; Bottinger, Erwin B.; Brody, Jennifer A.; Calkins, Hugh; Campbell, Archie; Cappola, Thomas P.; Carlquist, John; Chasman, Daniel I.; Chen, Lin Y.; Chen, Yii-Der Ida; Choi, Eue-Keun; Choi, Seung Hoan; Christophersen, Ingrid E.; Chung, Mina K.; Cole, John W.; Conen, David; Cook, James; Crijns, Harry J.; Cutler, Michael J.; Damrauer, Scott M.; Daniels, Brian R.; Darbar, Dawood; Delgado, Graciela; Denny, Joshua C.; Dichgans, Martin; Doerr, Marcus; Dudink, Elton A.; Dudley, Samuel C.; Esa, Nada; Esko, Tonu; Eskola, Markku; Fatkin, Diane; Felix, Stephan B.; Ford, Ian; Franco, Oscar H.; Geelhoed, Bastiaan; Grewal, Raji P.; Gudnason, Vilmundur; Guo, Xiuqing; Gupta, Namrata; Gustafsson, Stefan; Gutmann, Rebecca; Hamsten, Anders; Harris, Tamara B.; Hayward, Caroline; Heckbert, Susan R.; Hernesniemi, Jussi; Hocking, Lynne J.; Hofman, Albert; Horimoto, Andrea R. V. R.; Huang, Jie; Huang, Paul L.; Huffman, Jennifer; Ingelsson, Erik; Ipek, Esra Gucuk; Ito, Kaoru; Jimenez-Conde, Jordi; Johnson, Renee; Jukema, J. Wouter; Kaeaeb, Stefan; Kahonen, Mika; Kamatani, Yoichiro; Kane, John P.; Kastrati, Adnan; Kathiresan, Sekar; Katschnig-Winter, Petra; Kavousi, Maryam; Kessler, Thorsten; Kietselaer, Bas L.; Kirchhof, Paulus; Kleber, Marcus E.; Knight, Stacey; Krieger, Jose E.; Kubo, Michiaki; Launer, Lenore J.; Laurikka, Jari; Lehtimaki, Terho; Leineweber, Kirsten; Lemaitre, Rozenn N.; Li, Man; Lim, Hong Euy; Lin, Henry J.; Lin, Honghuang; Lind, Lars; Lindgren, Cecilia M.; Lokki, Marja-Liisa; London, Barry; Loos, Ruth J. F.; Low, Siew-Kee; Lu, Yingchang; Lyytikainen, Leo-Pekka; Macfarlane, Peter W.; Magnusson, Patrik K.; Mahajan, Anubha; Malik, Rainer; Mansur, Alfredo J.; Marcus, Gregory M.; Margolin, Lauren; Margulies, Kenneth B.; Maerz, Winfried; McManus, David D.; Melander, Olle; Mohanty, Sanghamitra; Montgomery, Jay A.; Morley, Michael P.; Morris, Andrew P.; Mueller-Nurasyid, Martina; Natale, Andrea; Nazarian, Saman; Neumann, Benjamin; Newton-Cheh, Christopher; Niemeijer, Maartje N.; Nikus, Kjell; Nilsson, Peter; Noordam, Raymond; Oellers, Heidi; Olesen, Morten S.; Orho-Melander, Marju; Padmanabhan, Sandosh; Pak, Hui-Nam; Pare, Guillaume; Pedersen, Nancy L.; Pera, Joanna; Pereira, Alexandre; Porteous, David; Psaty, Bruce M.; Pulit, Sara L.; Pullinger, Clive R.; Rader, Daniel J.; Refsgaard, Lena; Ribases, Marta; Ridker, Paul M.; Rienstra, Michiel; Risch, Lorenz; Roden, Dan M.; Rosand, Jonathan; Rosenberg, Michael A.; Rost, Natalia; Rotter, Jerome I.; Saba, Samir; Sandhu, Roopinder K.; Schnabel, Renate B.; Schramm, Katharina; Schunkert, Heribert; Schurman, Claudia; Scott, Stuart A.; Seppala, Ilkka; Shaffer, Christian; Shah, Svati; Shalaby, Alaa A.; Shim, Jaemin; Shoemaker, M. Benjamin; Siland, Joylene E.; Sinisalo, Juha; Sinner, Moritz F.; Slowik, Agnieszka; Smith, Albert V.; Smith, Blair H.; Smith, J. Gustav; Smith, Jonathan D.; Smith, Nicholas L.; Soliman, Elsayed Z.; Sotoodehnia, Nona; Stricker, Bruno H.; Sun, Albert; Sun, Han; Svendsen, Jesper H.; Tanaka, Toshihiro; Tanriverdi, Kahraman; Taylor, Kent D.; Teder-Laving, Maris; Teumer, Alexander; Theriault, Sebastien; Trompet, Stella; Tucker, Nathan R.; Tveit, Arnljot; Uitterlinden, Andre G.; Van Der Harst, Pim; Van Gelder, Isabelle C.; Van Wagoner, David R.; Verweij, Niek; Vlachopoulou, Efthymia; Voelker, Uwe; Wang, Biqi; Weeke, Peter E.; Weijs, Bob; Weiss, Raul; Weiss, Stefan; Wells, Quinn S.; Wiggins, Kerri L.; Wong, Jorge A.; Woo, Daniel; Worrall, Bradford B.; Yang, Pil-Sung; Yao, Jie; Yoneda, Zachary T.; Zeller, Tanja; Zeng, Lingyao; Lubitz, Steven A.; Lunetta, Kathryn L.; Ellinor, Patrick T.
- Issue Date
- 9월-2018
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE GENETICS, v.50, no.9, pp.1225 - +
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE GENETICS
- Volume
- 50
- Number
- 9
- Start Page
- 1225
- End Page
- +
- ISSN
- 1061-4036
- Abstract
- Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.