Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ng, Yee Ching | - |
dc.contributor.author | Kim, Ye Won | - |
dc.contributor.author | Lee, Jeong-Su | - |
dc.contributor.author | Lee, Sung Joon | - |
dc.contributor.author | Song, Moon Jung | - |
dc.date.accessioned | 2021-09-02T07:24:49Z | - |
dc.date.available | 2021-09-02T07:24:49Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73637 | - |
dc.description.abstract | Human noroviruses are the causative agents of non-bacterial gastroenteritis worldwide. The rapid onset and resolution of disease symptoms suggest that innate immune responses are critical for controlling norovirus infection; however, no effective antivirals are yet available. The present study was conducted to examine the antiviral activities of Schizonepeta tenuifolia Briquet extract (STE) against noroviruses. Treatment of human norovirus replicon-bearing HG23 cells with STE at 5 and 10 mg/ml concentrations resulted in the reduction in the viral RNA levels by 77.2% and 85.9%, respectively. STE had no cytotoxic effects on HG23 cells. Treatment of RAW 264.7 cells infected with murine norovirus 1 (MNV-1), a surrogate virus of human noroviruses, with STE at 10 and 20 mu g/ml concentrations resulted in the reduction of viral replication by 58.5% and 84.9%, respectively. STE treatment induced the expression of mRNAs for type I and type II interferons in HG23 cells and upregulated the transcription of interferon-beta in infected RAW 264.7 cells via increased phosphorylation of interferon regulatory factor 3, a critical transcription regulator for type I interferon production. These results suggest that STE inhibits norovirus replication through the induction of antiviral interferon production during virus replication and may serve as a candidate antiviral substance for treatment against noroviruses. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGICAL SOCIETY KOREA | - |
dc.subject | MURINE NOROVIRUS | - |
dc.subject | VIRUS | - |
dc.subject | GASTROENTERITIS | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | REPLICATION | - |
dc.subject | SUPPRESSION | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | INFECTION | - |
dc.subject | REPLICON | - |
dc.title | Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung Joon | - |
dc.contributor.affiliatedAuthor | Song, Moon Jung | - |
dc.identifier.doi | 10.1007/s12275-018-8228-7 | - |
dc.identifier.scopusid | 2-s2.0-85052237003 | - |
dc.identifier.wosid | 000442619700010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, v.56, no.9, pp.683 - 689 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 56 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 683 | - |
dc.citation.endPage | 689 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002379736 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | MURINE NOROVIRUS | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | GASTROENTERITIS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | REPLICON | - |
dc.subject.keywordAuthor | antiviral activity | - |
dc.subject.keywordAuthor | norovirus | - |
dc.subject.keywordAuthor | Schizonepeta tenuifolia Briquet (ST) | - |
dc.subject.keywordAuthor | natural phytochemicals | - |
dc.subject.keywordAuthor | interferons | - |
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