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Metal-free approach for the L-proline mediated synthesis of nitrones from nitrosobenzene

Authors
Choi, MinhoViji, MayavanKim, DonghwanLee, Young HeeSim, JaeukKwak, Young-ShinLee, KihoLee, HeesoonJung, Jae-Kyung
Issue Date
2-8월-2018
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Nitrones; Metal-free; L-proline; Nitrosobenzene; Azomethine ylide
Citation
TETRAHEDRON, v.74, no.31, pp.4182 - 4187
Indexed
SCIE
SCOPUS
Journal Title
TETRAHEDRON
Volume
74
Number
31
Start Page
4182
End Page
4187
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/73798
DOI
10.1016/j.tet.2018.06.001
ISSN
0040-4020
Abstract
An efficient, and metal-free approach for the L-proline mediated synthesis of nitrones from nitro-sobenzene and benzaldehydes has been established. The reaction undergoes very efficiently at room temperature in methanol as a solvent. The reaction is assumed to involve that the initial formation of azomethine ylide and [2 + 3] cycloaddition of nitrosobenzene, followed by the subsequent retro [2 + 3] cycloaddition could offer the desired nitrone. (c) 2018 Elsevier Ltd. All rights reserved.
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