Ecdysone-responsive microRNA-252-5p controls the cell cycle by targeting Abi in Drosophila
DC Field | Value | Language |
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dc.contributor.author | Lim, Do-Hwan | - |
dc.contributor.author | Lee, Seungjae | - |
dc.contributor.author | Han, Jee Yun | - |
dc.contributor.author | Choi, Min-Seok | - |
dc.contributor.author | Hong, Jae-Sang | - |
dc.contributor.author | Seong, Youngmo | - |
dc.contributor.author | Kwon, Young-Soo | - |
dc.contributor.author | Lee, Young Sik | - |
dc.date.accessioned | 2021-09-02T08:03:42Z | - |
dc.date.available | 2021-09-02T08:03:42Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/73887 | - |
dc.description.abstract | The steroid hormone ecdysone has a central role in the developmental transitions of insects through its control of responsive protein-coding and microRNA (miRNA) gene expression. However, the complete regulatory network controlling the expression of these genes remains to be elucidated. In this study, we performed cross-linking immunoprecipitation coupled with deep sequencing of endogenous Argonaute 1 (Ago1) protein, the core effector of the miRNA pathway, in Drosophila S2 cells. We found that regulatory interactions between miRNAs and their cognate targets were substantially altered by Ago1 in response to ecdysone signaling. Additionally, during the larva-to-adult metamorphosis, miR-252-5p was up-regulated via the canonical ecdysone-signaling pathway. Moreover, we provide evidence that miR-252-5p targets Abelson interacting protein (Abi) to decrease the protein levels of cyclins A and B, controlling the cell cycle. Overall, our data suggest a potential role for the ecdysone/miR-252-5p/Abi regulatory axis partly in cell-cycle control during metamorphosis in Drosophila.Lim, D.-H., Lee, S., Han, J. Y., Choi, M.-S., Hong, J.-S., Seong, Y., Kwon, Y.-S., Lee, Y. S. Ecdysone-responsive microR-252-5p controls the cell cycle by targeting Abi in Drosophila. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | INDUCIBLE GENE | - |
dc.subject | BINDING-SITES | - |
dc.subject | EARLY PUFF | - |
dc.subject | ENCODES 2 | - |
dc.subject | RNA | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | RECEPTOR | - |
dc.subject | COMPLEX | - |
dc.subject | PROTEIN | - |
dc.title | Ecdysone-responsive microRNA-252-5p controls the cell cycle by targeting Abi in Drosophila | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Sik | - |
dc.identifier.doi | 10.1096/fj.201701185RR | - |
dc.identifier.scopusid | 2-s2.0-85050850703 | - |
dc.identifier.wosid | 000439325400038 | - |
dc.identifier.bibliographicCitation | FASEB JOURNAL, v.32, no.8, pp.4519 - 4533 | - |
dc.relation.isPartOf | FASEB JOURNAL | - |
dc.citation.title | FASEB JOURNAL | - |
dc.citation.volume | 32 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 4519 | - |
dc.citation.endPage | 4533 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INDUCIBLE GENE | - |
dc.subject.keywordPlus | BINDING-SITES | - |
dc.subject.keywordPlus | EARLY PUFF | - |
dc.subject.keywordPlus | ENCODES 2 | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | 20E | - |
dc.subject.keywordAuthor | Ago1 | - |
dc.subject.keywordAuthor | CLIP-seq | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | cyclin | - |
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