Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (F-18)
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Son, Young Don | - |
dc.contributor.author | Kim, Jeong-Hee | - |
dc.contributor.author | Lee, Hyo-Jong | - |
dc.contributor.author | Kang, Nam-In | - |
dc.contributor.author | Chung, Gyung Ho | - |
dc.contributor.author | Park, Jong-Il | - |
dc.contributor.author | Cui, Yin | - |
dc.contributor.author | Kim, Woo-Sung | - |
dc.contributor.author | Chung, Young-Chul | - |
dc.date.accessioned | 2021-09-02T08:34:07Z | - |
dc.date.available | 2021-09-02T08:34:07Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1738-1088 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/74207 | - |
dc.description.abstract | Objective: Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia. Methods: We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed induing Psychotic Symptom Rating Scale for Auditory Hallucinations. Using fludeoxyglucose (F-18) positron emission tomography, regional differences in neural activity between the groups were analyzed. Results: The regions of interest analysis showed significantly lower standardized uptake value ratio (SUVR) in the superior, middle, and inferior frontal gyri, and higher SUVR in the putamen in patients with AHs versus patients without AHs. These findings were confirmed in the voxel-wise analysis. Conclusion: Our findings indicate that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN COLL NEUROPSYCHOPHARMACOLOGY | - |
dc.subject | SUPERIOR FRONTAL GYRUS | - |
dc.subject | VERBAL HALLUCINATIONS | - |
dc.subject | FUNCTIONAL-ANATOMY | - |
dc.subject | TEMPORAL CORTEX | - |
dc.subject | HEARING VOICES | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | BRAIN | - |
dc.subject | PET | - |
dc.subject | ACTIVATION | - |
dc.subject | METAANALYSIS | - |
dc.title | Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (F-18) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jeong-Hee | - |
dc.identifier.doi | 10.9758/cpn.2018.16.3.324 | - |
dc.identifier.scopusid | 2-s2.0-85051404969 | - |
dc.identifier.wosid | 000440733000012 | - |
dc.identifier.bibliographicCitation | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.16, no.3, pp.324 - 332 | - |
dc.relation.isPartOf | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | - |
dc.citation.title | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 324 | - |
dc.citation.endPage | 332 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002376322 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SUPERIOR FRONTAL GYRUS | - |
dc.subject.keywordPlus | VERBAL HALLUCINATIONS | - |
dc.subject.keywordPlus | FUNCTIONAL-ANATOMY | - |
dc.subject.keywordPlus | TEMPORAL CORTEX | - |
dc.subject.keywordPlus | HEARING VOICES | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordAuthor | Auditory hallucinations | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | Positron-emission tomography | - |
dc.subject.keywordAuthor | Bottom-up | - |
dc.subject.keywordAuthor | Top-down | - |
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