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Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (F-18)

Authors
Kim, Jong-HoonSon, Young DonKim, Jeong-HeeLee, Hyo-JongKang, Nam-InChung, Gyung HoPark, Jong-IlCui, YinKim, Woo-SungChung, Young-Chul
Issue Date
8월-2018
Publisher
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
Keywords
Auditory hallucinations; Schizophrenia; Positron-emission tomography; Bottom-up; Top-down
Citation
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.16, no.3, pp.324 - 332
Indexed
SCIE
SCOPUS
KCI
Journal Title
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Volume
16
Number
3
Start Page
324
End Page
332
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/74207
DOI
10.9758/cpn.2018.16.3.324
ISSN
1738-1088
Abstract
Objective: Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia. Methods: We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed induing Psychotic Symptom Rating Scale for Auditory Hallucinations. Using fludeoxyglucose (F-18) positron emission tomography, regional differences in neural activity between the groups were analyzed. Results: The regions of interest analysis showed significantly lower standardized uptake value ratio (SUVR) in the superior, middle, and inferior frontal gyri, and higher SUVR in the putamen in patients with AHs versus patients without AHs. These findings were confirmed in the voxel-wise analysis. Conclusion: Our findings indicate that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs.
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