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Romaine Lettuce/Skullcap Mixture Improves Sleep Behavior in Vertebrate Models

Authors
Hong, Ki-BaeHan, Sung HeePark, YooheonSuh, Hyung JooChoi, Hyeon-Son
Issue Date
8월-2018
Publisher
PHARMACEUTICAL SOC JAPAN
Keywords
romaine lettuce; skullcap; sleep behavior; non-rapid eye movement; gamma-aminobutyric acid (GABA) receptor; rodent model
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.41, no.8, pp.1269 - 1276
Indexed
SCIE
SCOPUS
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume
41
Number
8
Start Page
1269
End Page
1276
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/74218
DOI
10.1248/bpb.b18-00267
ISSN
0918-6158
Abstract
The aim of this study is to investigate the effects of romaine lettuce leaves extract (RE), skullcap root extract (SE) and their mixture on sleep behaviors in vertebrate models. HPLC analysis showed that RE contains lactucopicrin (0.02 +/- 0.01 mg/g extract), chlorogenic acid (4.05 +/- 0.03 mg/g extract), caffeic acid (2.38 +/- 0.03 mg/g extract), and chicoric acid (7.02 +/- 0.32 mg/g extract) as main phenolic compounds, while SE includes baicalin (99.4 +/- 0.5 mg/g extract), baicalein (8.28 +/- 0.21mg/g extract), and wogonin (3.09 +/- 0.32 mg/g extract). The mixture of RE (100 mg/g extract) and SE (40 mg/g extract) increased total sleep time by 50.9% compared with the control in pentobarbital-induced sleep model. In electroencephalography (EEG) analysis, RE/SE mixture significantly increased Non-Rapid Eye Movement (NREM), in which delta wave was enhanced by around 40% compared with normal control, leading to the increase of sleep time. In caffeine-induced wake model, RE/SE mixture greatly decreased (53%) caffeine-induced wake time, showing a similar level to normal control. In addition, caffeine-induced decreased of NREM and delta wave effectively increased with RE/SE mixture; NREM and delta wave increased by 85% and 108%, respectively. Furthermore, RE/SE mixture was shown to bind to a gamma-aminobutyric acid type A (GABA(A))-benzodiazepine (BZD) receptor stronger than RE or SE single extract. Taken together, RE/SE mixture effectively improved sleep behavior with the increase of NREM via GABA(A)-BZD receptor binding. RE/SE mixture can be used as an herbal agent for sleep disorders.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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