Ischemic stroke risk during long-term follow up in patients with successful catheter ablation for atrial fibrillation in Korea
- Authors
- Kim, Dong-Hyeok; Lee, Dae-In; Ahn, Jinhee; Lee, Kwang-No; Roh, Seung-Young; Shim, Jaemin; Choi, Jong-Il; Kim, Young-Hoon
- Issue Date
- 19-7월-2018
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.13, no.7
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 13
- Number
- 7
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/74322
- DOI
- 10.1371/journal.pone.0201061
- ISSN
- 1932-6203
- Abstract
- The interruption of oral anticoagulation therapy (OAC) after CA of atrial fibrillation (AF) is controversial. The purpose of this study was to evaluate the relationship between successful long-term outcomes of catheter resection and SR maintenance and ischemic stroke risk in Korea. We studied 1,548 consecutive patients who were followed up for more than 2 years after CA of AF. We investigated the incidence of ischemic stroke during long-term follow-up. Compared to the AF recurrence group (n = 619), the sinus rhythm (SR) maintenance group (n = 929) had more paroxysmal AF (74.6% versus 44.4%, p<0.001), smaller LA size (39.9 +/- 5.7mm versus 42.3 +/- 6.0mm, p<0.001), and younger age (54.2 +/- 10.9 years versus 56.4 +/- 10.6 years, p<0.001). However, CHA(2)DS(2)-VASc scores were not significantly different between the two groups (0.9 vs. 1.1, p = 0.053). The overall incidence of ischemic stroke during the mean follow-up period of 54 months after CA was 0.6%, and was significantly lower in the SR group than the AF recurrence group (0.3% vs. 1.1%, log-rank test p<0.001). However, in sub-analysis in the SR group, the rate of ischemic stroke was significantly increasing in patients with a CHA(2)DS(2)-VASc score >= 4 compared to those with a CHA(2)DS(2)-VASc score < 4 (4.3% vs. 0.2%, log-rank test p<0.001). In conclusion, this long-term followup data in patients with AF who underwent successful CA showed that SR maintenance was correlated with a lower rate of ischemic stroke in Korea. However, it was only observed in patients with CHA(2)DS(2)-VASc score <= 3.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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