Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production
DC Field | Value | Language |
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dc.contributor.author | Lee, Da Hye | - |
dc.contributor.author | Shin, Ji-Sun | - |
dc.contributor.author | Kang, Shin-Young | - |
dc.contributor.author | Lee, Seng-Bin | - |
dc.contributor.author | Lee, Jin Su | - |
dc.contributor.author | Ryu, Seung Mok | - |
dc.contributor.author | Lee, Kyung Tae | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.date.accessioned | 2021-09-02T10:33:02Z | - |
dc.date.available | 2021-09-02T10:33:02Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75000 | - |
dc.description.abstract | An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC50 values of 14.7 to 17.8 mu M. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | CYTOTOXIC ACTIVITY | - |
dc.subject | ACTIVE AGENTS | - |
dc.subject | CONSTITUENTS | - |
dc.title | Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1021/acs.jnatprod.8b00229 | - |
dc.identifier.scopusid | 2-s2.0-85049026737 | - |
dc.identifier.wosid | 000436527100020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.81, no.6, pp.1468 - 1473 | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 81 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1468 | - |
dc.citation.endPage | 1473 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CYTOTOXIC ACTIVITY | - |
dc.subject.keywordPlus | ACTIVE AGENTS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
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