Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production
- Authors
- Lee, Da Hye; Shin, Ji-Sun; Kang, Shin-Young; Lee, Seng-Bin; Lee, Jin Su; Ryu, Seung Mok; Lee, Kyung Tae; Lee, Dongho; Jang, Dae Sik
- Issue Date
- 6월-2018
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.81, no.6, pp.1468 - 1473
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 81
- Number
- 6
- Start Page
- 1468
- End Page
- 1473
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75000
- DOI
- 10.1021/acs.jnatprod.8b00229
- ISSN
- 0163-3864
- Abstract
- An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC50 values of 14.7 to 17.8 mu M.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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