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An EEG-NIRS Multimodal SoC for Accurate Anesthesia Depth Monitoring

Authors
Ha, UnsooLee, JaehyukKim, MinseoRoh, TaehwanChoi, SangsikYoo, Hoi-Jun
Issue Date
6월-2018
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Keywords
Anesthesia depth monitoring; electroen-cephalography (EEG) instrumentation amplifier (IA); multimodal system-on-chip (SoC); near-infrared spectroscopy (NIRS) transimpedance amplifier (TIA)
Citation
IEEE JOURNAL OF SOLID-STATE CIRCUITS, v.53, no.6, pp.1830 - 1843
Indexed
SCIE
SCOPUS
Journal Title
IEEE JOURNAL OF SOLID-STATE CIRCUITS
Volume
53
Number
6
Start Page
1830
End Page
1843
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/75020
DOI
10.1109/JSSC.2018.2810213
ISSN
0018-9200
Abstract
In surgical operation environments, anesthesia enables doctors to safe and accurate medical process with minimized movement and pain of patients. In general anesthesia, non-invasive and reliable monitoring of anesthesia depth is required because it is directly related to patient's life. However, the current anesthesia depth monitoring approach, bispectral index (BIS), uses only electroencephalography (EEG) from the frontal lobe, and it shows critical limitations in the monitoring of anesthesia depth such as signal distortion due to electrocautery, electromyography (EMG) and dried gel, and false response to the special types of anesthetic drugs. In this paper, a multimodal head-patch system that simultaneously measures EEG and near-infrared spectroscopy (NIRS) on the frontal lobe is proposed. For EEG monitoring, mixed-mode dc-servo loop is proposed to cancel out the +/- 300-mV electrode-dc offset for dried gel condition with 3.59 noise-efficiency factor. To compensate the electromagnetic noises (EMG and electrocautery) in the system level, NIRS signal is measured. Logarithmic transimpedance amplifier (TIA) and closed-loop controlled (CLC) NIRS current driver are proposed. Logarithmic TIA can reject ambient light up to 10 nA to achieve a 60-dB dynamic range. According to the comparator output, CLC NIRS driver duty cycle can be adjusted from 0.625 m to 50 ms adaptively. The 16-mm(2) system-on-chip is fabricated in 65-nm CMOS. It dissipates 25.2-mW peak power. With the combined signals, it can show the clinically important transition from the awake to deep state, but BIS cannot detect the transition in a clinical trial.
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