Evidence for additionally increased apoptosis in the peripheral blood mononuclear cells of major depressive patients with a high risk for suicide
DC Field | Value | Language |
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dc.contributor.author | Amidfar, Meysam | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Scaini, Giselli | - |
dc.contributor.author | Quevedo, Joao | - |
dc.date.accessioned | 2021-09-02T11:15:53Z | - |
dc.date.available | 2021-09-02T11:15:53Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1552-4841 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75426 | - |
dc.description.abstract | Several studies have suggested a pathophysiological role of blood cell apoptosis in major depressive disorder (MDD). The aim of this study was to evaluate mRNA expression levels of Bcl-2, Bax, and Fas in peripheral blood mononuclear cells (PBMCs) of MDD patients with a high risk for suicide relative to those without a high risk for suicide as well as healthy subjects. The mRNA expression of Bcl-2, Bax, and Fas as well as the Bcl-2/Bax ratio was examined in the PBMCs of 30 MDD patients with a high risk for suicide, 30 MDD patients without a high risk for suicide, and 30 healthy controls. The mRNA expression of target genes was measured using real-time quantitative Polymerase Chain Reaction (PCR). FAS mRNA expression was significantly increased, and Bcl-2 mRNA expression and the Bcl-2/Bax expression ratio were significantly decreased, in the PBMCs of MDD patients with or without a high risk for suicide attempts compared to healthy controls (p<.001). However, Bax mRNA expression was significantly increased only in MDD patients with a high risk for suicide. Moreover, MDD patients with a high risk for suicide had increased Bax and FAS mRNA expression and decreased Bcl-2 and Bcl-2/Bax ratio when compared to patients without risk for suicide (p<.001). Our findings may support the role of both internal and external apoptotic pathways in the interplay between the immune system and depressive symptoms, especially in patients with a high risk for suicide. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | NATIONAL COMORBIDITY SURVEY | - |
dc.subject | NEURAL STEM-CELL | - |
dc.subject | BCL-2 FAMILY | - |
dc.subject | ALTERED EXPRESSION | - |
dc.subject | PREFRONTAL CORTEX | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | MOOD DISORDERS | - |
dc.subject | CYTOKINES | - |
dc.subject | PROTEIN | - |
dc.subject | BRAIN | - |
dc.title | Evidence for additionally increased apoptosis in the peripheral blood mononuclear cells of major depressive patients with a high risk for suicide | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1002/ajmg.b.32623 | - |
dc.identifier.scopusid | 2-s2.0-85045120055 | - |
dc.identifier.wosid | 000434076400002 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, v.177, no.4, pp.388 - 396 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | - |
dc.citation.title | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | - |
dc.citation.volume | 177 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 388 | - |
dc.citation.endPage | 396 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | NATIONAL COMORBIDITY SURVEY | - |
dc.subject.keywordPlus | NEURAL STEM-CELL | - |
dc.subject.keywordPlus | BCL-2 FAMILY | - |
dc.subject.keywordPlus | ALTERED EXPRESSION | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MOOD DISORDERS | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | major depressive disorder | - |
dc.subject.keywordAuthor | PBMCs | - |
dc.subject.keywordAuthor | suicide | - |
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