Evidence for additionally increased apoptosis in the peripheral blood mononuclear cells of major depressive patients with a high risk for suicide
- Authors
- Amidfar, Meysam; Kim, Yong-Ku; Scaini, Giselli; Quevedo, Joao
- Issue Date
- 6월-2018
- Publisher
- WILEY
- Keywords
- apoptosis; major depressive disorder; PBMCs; suicide
- Citation
- AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, v.177, no.4, pp.388 - 396
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Volume
- 177
- Number
- 4
- Start Page
- 388
- End Page
- 396
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75426
- DOI
- 10.1002/ajmg.b.32623
- ISSN
- 1552-4841
- Abstract
- Several studies have suggested a pathophysiological role of blood cell apoptosis in major depressive disorder (MDD). The aim of this study was to evaluate mRNA expression levels of Bcl-2, Bax, and Fas in peripheral blood mononuclear cells (PBMCs) of MDD patients with a high risk for suicide relative to those without a high risk for suicide as well as healthy subjects. The mRNA expression of Bcl-2, Bax, and Fas as well as the Bcl-2/Bax ratio was examined in the PBMCs of 30 MDD patients with a high risk for suicide, 30 MDD patients without a high risk for suicide, and 30 healthy controls. The mRNA expression of target genes was measured using real-time quantitative Polymerase Chain Reaction (PCR). FAS mRNA expression was significantly increased, and Bcl-2 mRNA expression and the Bcl-2/Bax expression ratio were significantly decreased, in the PBMCs of MDD patients with or without a high risk for suicide attempts compared to healthy controls (p<.001). However, Bax mRNA expression was significantly increased only in MDD patients with a high risk for suicide. Moreover, MDD patients with a high risk for suicide had increased Bax and FAS mRNA expression and decreased Bcl-2 and Bcl-2/Bax ratio when compared to patients without risk for suicide (p<.001). Our findings may support the role of both internal and external apoptotic pathways in the interplay between the immune system and depressive symptoms, especially in patients with a high risk for suicide.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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