Elevated fecal calprotectin levels are associated with severity atopic dermatitis in children
- Authors
- Seo, SungChul; Ahn, So Hyun; Ri, Soohyun; Yoon, Yoonsun; Byeon, Jung Hye; Kim, Seung Hyun; Yoon, Wonsuck; Yoo, Young
- Issue Date
- 6월-2018
- Publisher
- ALLERGY IMMUNOL SOC THAILAND,
- Keywords
- Atopic dermatitis; Calprotectin; Children; Gut inflammation; Gut microbiota
- Citation
- ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, v.36, no.2, pp.82 - 87
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
- Volume
- 36
- Number
- 2
- Start Page
- 82
- End Page
- 87
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/75457
- DOI
- 10.12932/AP-100317-0044
- ISSN
- 0125-877X
- Abstract
- Background: Recent data suggested that imbalance in gut microbiota and gastrointestinal inflammation are associated with the childhood allergic disease. Fecal calprotectin has been used for a non-invasive marker of gut inflammation. Objective: The aim of this study was to investigate the relationships between fecal calprotectin level and the clinical severity of atopic dermatitis (AD) in children. Methods: We enrolled 65 subjects with AD. The concentration of calprotectin was measured in each subject's fecal sample. Results: The geometric mean fecal calprotectin level of the total subjects was 33.1(10.1-108.9) mu g/g. Among the 65 subjects, 44(67.7%) showed calprotectin levels lower than 50 mu g/g(Group 1), and 21(32.3%) were higher than 50 mu g/g(Group 2). The mean SCORAD index was significantly higher in Group 2 than Group 1(31.0 +/- 16.0 vs 22.2 +/- 15.3, p=0.046). The geometric mean serum total IgE levels was higher in Group 2 compared to Group 1(361.4[31.6-992.3]IU/mL, vs 175.9[44.3-699.2]IU/ mL, p=0.040). The mean blood eosinophils were significantly higher in Group 2 than in Group 1(497.7[239.8-1032.8]/mu L vs 281.5[121.5-652.0]/mu L, p=0.034). The incidence of exposure to environmental tobacco smoke was significantly higher in Group 2 compared to Group 1(76.2% vs 47.7%, p=0.036). Geometric mean fecal calprotectin level in severe AD was significantly higher than that of mild-to-moderate AD(66.7[13.5-330.3]mu g/g vs 29.4[10.1-85.6]mu g/g, p=0.044). The fecal calprotectin level significantly correlated with the SCORAD index(r=0.303, p=0.014). Conclusions: Higher fecal calprotectin levels were observed in subjects with severe AD. Elevated fecal calprotectin level as a gastrointestinal inflammatory marker may associate with childhood AD. Measurement of fecal calprotectin might be useful for assessment of severity of childhood AD.
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