Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats
DC Field | Value | Language |
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dc.contributor.author | Kwon, Jung Il | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Noh, Dong Ouk | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Han, Sung Hee | - |
dc.date.accessioned | 2021-09-02T11:21:14Z | - |
dc.date.available | 2021-09-02T11:21:14Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/75464 | - |
dc.description.abstract | The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.subject | SLOW-TRANSIT CONSTIPATION | - |
dc.subject | CHAIN FATTY-ACIDS | - |
dc.subject | INTERSTITIAL-CELLS | - |
dc.subject | FECAL MICROFLORA | - |
dc.subject | PREBIOTICS | - |
dc.subject | FIBER | - |
dc.subject | CAJAL | - |
dc.subject | FERMENTATION | - |
dc.subject | MEGACOLON | - |
dc.subject | HEALTH | - |
dc.title | Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1007/s10068-017-0300-2 | - |
dc.identifier.scopusid | 2-s2.0-85047664059 | - |
dc.identifier.wosid | 000434851600018 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.27, no.3, pp.781 - 788 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 781 | - |
dc.citation.endPage | 788 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002363345 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | SLOW-TRANSIT CONSTIPATION | - |
dc.subject.keywordPlus | CHAIN FATTY-ACIDS | - |
dc.subject.keywordPlus | INTERSTITIAL-CELLS | - |
dc.subject.keywordPlus | FECAL MICROFLORA | - |
dc.subject.keywordPlus | PREBIOTICS | - |
dc.subject.keywordPlus | FIBER | - |
dc.subject.keywordPlus | CAJAL | - |
dc.subject.keywordPlus | FERMENTATION | - |
dc.subject.keywordPlus | MEGACOLON | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordAuthor | GOS | - |
dc.subject.keywordAuthor | Lactulose | - |
dc.subject.keywordAuthor | Oligosaccharides | - |
dc.subject.keywordAuthor | Constipation | - |
dc.subject.keywordAuthor | Short-chain fatty acids | - |
dc.subject.keywordAuthor | Crypt cell | - |
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