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Lifespan Extension of Caenorhabditis elegans by Butyricicoccus pullicaecorum and Megasphaera elsdenii with Probiotic Potential

Authors
Kwon, GayeungLee, JiyunKoh, Jong-HoLim, Young-Hee
Issue Date
5월-2018
Publisher
SPRINGER
Citation
CURRENT MICROBIOLOGY, v.75, no.5, pp.557 - 564
Indexed
SCIE
SCOPUS
Journal Title
CURRENT MICROBIOLOGY
Volume
75
Number
5
Start Page
557
End Page
564
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/76000
DOI
10.1007/s00284-017-1416-6
ISSN
0343-8651
Abstract
Butyricicoccus pullicaecorum and Megasphaera elsdenii inhabit the human intestine and have probiotic potential. The aim of this study was to evaluate the effects of B. pullicaecorum and M. elsdenii on the lifespan of Caenorhabditis elegans. They significantly (P < 0.05) extended the lifespan of C. elegans compared with Escherichia coli OP50, a standard food for the worm. Analysis of age-related biomarkers such as lipofuscin, body size, and locomotory activity showed that they retarded aging. They all failed to extend the lifespan of daf-12 or dbl-1 loss-of-function C. elegans mutants compared with E. coli OP50-fed worms. However, the increase in lifespan was observed in daf-16, jnk-1, pmk-1, and skn-1 mutants. Moreover, they increased the resistance of C. elegans to a human pathogen, Salmonella typhimurium. In conclusion, B. pullicaecorum and M. elsdenii extend the lifespan of C. elegans via the transforming growth factor-beta (TGF-beta) pathway associated with anti-inflammatory processes in the innate immune system.
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LIM, YOUNG HEE
보건과학대학 (바이오시스템의과학부)
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