Eukaryotic DNA damage responses: Homologous recombination factors and ubiquitin modification
- Authors
- Lee, Nam Soo; Kim, Soomi; Jung, Yong Woo; Kim, Hongtae
- Issue Date
- 5월-2018
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- DNA damage response; Homologous recombination repair pathway; Ubiquitin modification
- Citation
- MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v.809, pp.88 - 98
- Indexed
- SCIE
SCOPUS
- Journal Title
- MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Volume
- 809
- Start Page
- 88
- End Page
- 98
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/76032
- DOI
- 10.1016/j.mrfmmm.2017.04.003
- ISSN
- 0027-5107
- Abstract
- To prevent genomic instability disorders, cells have developed a DNA damage response. The response involves various proteins that sense damaged DNA, transduce damage signals, and effect DNA repair. In addition, ubiquitin modifications modulate the signaling pathway depending on cellular context. Among various types of DNA damage, double-stranded breaks are highly toxic to genomic integrity. Homologous recombination (HR) repair is an essential mechanism that fixes DNA damage because of its high level of accuracy. Although factors in the repair pathway are well established, pinpointing the exact mechanisms of repair and devising therapeutic applications requires more studies. Moreover, essential functions of ubiquitin modification in the DNA damage signaling pathway have emerged. In this review, to explore the eukaryotic DNA damage response, we will mention the functions of main factors in the HR repair pathway and ubiquitin modification.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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