Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells
DC Field | Value | Language |
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dc.contributor.author | Yang, Changwon | - |
dc.contributor.author | Lim, Whasun | - |
dc.contributor.author | Bazer, Fuller W. | - |
dc.contributor.author | Song, Gwonhwa | - |
dc.date.accessioned | 2021-09-02T12:57:47Z | - |
dc.date.available | 2021-09-02T12:57:47Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76282 | - |
dc.description.abstract | In early pregnancy, adequate dietary factors are important for the growth of human trophoblast cells, followed by placental development. Although stearoyl-CoA desaturase 1 (SCD1) is expected to relieve palmitic acid (PA)-induced lipotoxicity by regulating diacylglycerol and ceramide, its function is unclear in human trophoblast cells. The aim was to investigate inhibitory effects of SCD1 activity on PA-induced trophoblast cell death. PA induces cell death and inhibits the invasion of human trophoblast cells (HTR8/SVneo). In addition, we demonstrate that SCD1 has a protective role against PA in human trophoblast cells by regulating AKT-mediated signaling pathway and mitochondrial membrane potential. The knockdown of SCD1 enhances the proapoptotic activity of PA in HTR8/SVneo cells. Lastly, we investigated microRNA expression predicted to target SCD1 and diacylglycerol O-acyltransferase 1 (DGAT1) by PA. Collectively, the results suggest potential roles of SCD1 and DGAT1 in alleviating the toxicity of PA and maintaining lipid homeostasis for normal placentation. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject | SKELETAL-MUSCLE CELLS | - |
dc.subject | MATERNAL OBESITY | - |
dc.subject | CANCER-CELLS | - |
dc.subject | FATTY | - |
dc.subject | PROLIFERATION | - |
dc.subject | METABOLISM | - |
dc.subject | APOPTOSIS | - |
dc.subject | GROWTH | - |
dc.subject | CHORIOCARCINOMA | - |
dc.title | Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwonhwa | - |
dc.identifier.doi | 10.1016/j.jnutbio.2017.11.005 | - |
dc.identifier.scopusid | 2-s2.0-85037637386 | - |
dc.identifier.wosid | 000429504900005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.54, pp.35 - 47 | - |
dc.relation.isPartOf | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.title | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.citation.volume | 54 | - |
dc.citation.startPage | 35 | - |
dc.citation.endPage | 47 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE CELLS | - |
dc.subject.keywordPlus | MATERNAL OBESITY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | FATTY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CHORIOCARCINOMA | - |
dc.subject.keywordAuthor | Trophoblast | - |
dc.subject.keywordAuthor | Palmitic acid | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | SCD1 | - |
dc.subject.keywordAuthor | Mitochondria | - |
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