Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells

Authors
Yang, ChangwonLim, WhasunBazer, Fuller W.Song, Gwonhwa
Issue Date
4월-2018
Publisher
ELSEVIER SCIENCE INC
Keywords
Trophoblast; Palmitic acid; Apoptosis; SCD1; Mitochondria
Citation
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.54, pp.35 - 47
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume
54
Start Page
35
End Page
47
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/76282
DOI
10.1016/j.jnutbio.2017.11.005
ISSN
0955-2863
Abstract
In early pregnancy, adequate dietary factors are important for the growth of human trophoblast cells, followed by placental development. Although stearoyl-CoA desaturase 1 (SCD1) is expected to relieve palmitic acid (PA)-induced lipotoxicity by regulating diacylglycerol and ceramide, its function is unclear in human trophoblast cells. The aim was to investigate inhibitory effects of SCD1 activity on PA-induced trophoblast cell death. PA induces cell death and inhibits the invasion of human trophoblast cells (HTR8/SVneo). In addition, we demonstrate that SCD1 has a protective role against PA in human trophoblast cells by regulating AKT-mediated signaling pathway and mitochondrial membrane potential. The knockdown of SCD1 enhances the proapoptotic activity of PA in HTR8/SVneo cells. Lastly, we investigated microRNA expression predicted to target SCD1 and diacylglycerol O-acyltransferase 1 (DGAT1) by PA. Collectively, the results suggest potential roles of SCD1 and DGAT1 in alleviating the toxicity of PA and maintaining lipid homeostasis for normal placentation. (C) 2017 Elsevier Inc. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Gwon hwa photo

Song, Gwon hwa
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE