In-situ and highly sensitive detection of epidermal growth factor receptor mutation using nano-porous quartz crystal microbalance
DC Field | Value | Language |
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dc.contributor.author | Park, Hyunjun | - |
dc.contributor.author | You, Juneseok | - |
dc.contributor.author | Park, Chanho | - |
dc.contributor.author | Jang, Kuewhan | - |
dc.contributor.author | Na, Sungsoo | - |
dc.date.accessioned | 2021-09-02T13:29:33Z | - |
dc.date.available | 2021-09-02T13:29:33Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1738-494X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76606 | - |
dc.description.abstract | Assessment of epidermal growth factor receptor (EGFR) exon 19 mutations is very important indicator for treating lung cancer patients. In this report, we propose in-situ and highly sensitive detection method of EGFR mutation using quartz crystal microbalance (QCM) and nano-porous structured QCM electrode. The detection is based on the resonance frequency shift of QCM electrode upon DNA hybridization between probe DNA and EGFR mutant DNA (746-750 (del ELREA) in EGFR exon 19). Nano-porous structure is produced on the QCM electrode through simple processes of electrochemical deposition and etching. By using QCM, in-situ detection of EGFR mutation is performed within 30 mins. High sensitivity is achieved by introducing nano-porous structure on a QCM electrode, and the limit of detection (LOD) is 1 nM. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MECHANICAL ENGINEERS | - |
dc.subject | CELL LUNG-CANCER | - |
dc.subject | EGFR MUTATION | - |
dc.subject | LABEL-FREE | - |
dc.subject | DNA | - |
dc.subject | GENE | - |
dc.subject | PCR | - |
dc.title | In-situ and highly sensitive detection of epidermal growth factor receptor mutation using nano-porous quartz crystal microbalance | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.identifier.doi | 10.1007/s12206-018-0348-9 | - |
dc.identifier.scopusid | 2-s2.0-85045768395 | - |
dc.identifier.wosid | 000430417300047 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY, v.32, no.4, pp.1927 - 1932 | - |
dc.relation.isPartOf | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | - |
dc.citation.title | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1927 | - |
dc.citation.endPage | 1932 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002332320 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Mechanical | - |
dc.subject.keywordPlus | CELL LUNG-CANCER | - |
dc.subject.keywordPlus | EGFR MUTATION | - |
dc.subject.keywordPlus | LABEL-FREE | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PCR | - |
dc.subject.keywordAuthor | Epidermal growth factor receptor (EGFR) | - |
dc.subject.keywordAuthor | In-situ detection | - |
dc.subject.keywordAuthor | Mutation | - |
dc.subject.keywordAuthor | Nano-porous | - |
dc.subject.keywordAuthor | Quartz crystal microbalance (QCM) | - |
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