A Fluorescent Probe for Stimulated Emission Depletion Super-Resolution Imaging of Vicinal-Dithiol-Proteins on Mitochondria! Membrane
DC Field | Value | Language |
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dc.contributor.author | Yang, Zhigang | - |
dc.contributor.author | Kang, Dong Hoon | - |
dc.contributor.author | Lee, Hoyeon | - |
dc.contributor.author | Shin, Jinwoo | - |
dc.contributor.author | Yan, Wei | - |
dc.contributor.author | Rathore, Bhowmira | - |
dc.contributor.author | Kim, Hye-Ri | - |
dc.contributor.author | Kim, Seo Jin | - |
dc.contributor.author | Singh, Hardev | - |
dc.contributor.author | Liu, Liwei | - |
dc.contributor.author | Qu, Junle | - |
dc.contributor.author | Kang, Chulhun | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-02T13:32:48Z | - |
dc.date.available | 2021-09-02T13:32:48Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76633 | - |
dc.description.abstract | Realizing the significant roles of vicinal-dithiol proteins (VDPs) in maintaining the cellular redox homeostasis and their implication in many diseases, we synthesized a smart arsenate based fluorescent probe 1 which can preferentially target the mitochondrial membrane-bound vicinal dithiol proteins (VDPs), especially voltage-dependent anion channel (VDAC2). The probe targetability was demonstrated by in vitro studies such as colocalization, stimulated emission depletion (STED) super-resolution imaging, proteomic MS/MS analysis, and Western blot analysis. The probe represents a rare example of fluorescence labeling of mitochondrial membrane-bound VDPs and can provide a new way to construct VDPs-specific fluorescent probes to gain deeper understanding of their roles in mitochondrial-related disorders. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | LIVING CELLS | - |
dc.subject | INTERMEMBRANE SPACE | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | ARSENIC-BINDING | - |
dc.subject | IDENTIFICATION | - |
dc.subject | QUANTIFICATION | - |
dc.subject | MODULATION | - |
dc.subject | ACTIVATION | - |
dc.subject | ORGANELLES | - |
dc.subject | OXIDATION | - |
dc.title | A Fluorescent Probe for Stimulated Emission Depletion Super-Resolution Imaging of Vicinal-Dithiol-Proteins on Mitochondria! Membrane | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1021/acs.bioconjchem.8b00128 | - |
dc.identifier.scopusid | 2-s2.0-85045579710 | - |
dc.identifier.wosid | 000430641700067 | - |
dc.identifier.bibliographicCitation | BIOCONJUGATE CHEMISTRY, v.29, no.4, pp.1446 - 1453 | - |
dc.relation.isPartOf | BIOCONJUGATE CHEMISTRY | - |
dc.citation.title | BIOCONJUGATE CHEMISTRY | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1446 | - |
dc.citation.endPage | 1453 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | INTERMEMBRANE SPACE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ARSENIC-BINDING | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ORGANELLES | - |
dc.subject.keywordPlus | OXIDATION | - |
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