COX-2 targeting indomethacin conjugated fluorescent probe
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyeong Seok | - |
dc.contributor.author | Park, Taegun | - |
dc.contributor.author | Ren, Wen Xiu | - |
dc.contributor.author | Lim, Ja-Yun | - |
dc.contributor.author | Won, Miae | - |
dc.contributor.author | Heo, June Seok | - |
dc.contributor.author | Lee, Seung Gwan | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-02T14:02:29Z | - |
dc.date.available | 2021-09-02T14:02:29Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 0143-7208 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/76843 | - |
dc.description.abstract | The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | CYCLOOXYGENASE-2 OVEREXPRESSION | - |
dc.subject | CANCER STATISTICS | - |
dc.subject | IMAGING AGENTS | - |
dc.subject | INFLAMMATION | - |
dc.subject | INHIBITORS | - |
dc.subject | EXPRESSION | - |
dc.subject | PREVENTION | - |
dc.subject | LIGHT | - |
dc.subject | GENE | - |
dc.title | COX-2 targeting indomethacin conjugated fluorescent probe | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Won, Miae | - |
dc.contributor.affiliatedAuthor | Lee, Seung Gwan | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1016/j.dyepig.2017.11.053 | - |
dc.identifier.scopusid | 2-s2.0-85037972342 | - |
dc.identifier.wosid | 000427332200034 | - |
dc.identifier.bibliographicCitation | DYES AND PIGMENTS, v.150, pp.261 - 266 | - |
dc.relation.isPartOf | DYES AND PIGMENTS | - |
dc.citation.title | DYES AND PIGMENTS | - |
dc.citation.volume | 150 | - |
dc.citation.startPage | 261 | - |
dc.citation.endPage | 266 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Textiles | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 OVEREXPRESSION | - |
dc.subject.keywordPlus | CANCER STATISTICS | - |
dc.subject.keywordPlus | IMAGING AGENTS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | COX-2 enzyme | - |
dc.subject.keywordAuthor | Indomethacin | - |
dc.subject.keywordAuthor | Fluorescent imaging | - |
dc.subject.keywordAuthor | Bioimaging | - |
dc.subject.keywordAuthor | Cancer detection | - |
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